Preformulation studies regarding a physico-chemical evaluation of memantine, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, are presented in this work. This characterization of memantine is pre-required for the formulation of a parenteral solution. The water solubility, the thermal behavior and the chemical stability in aqueous solution, depending on the pH, temperature, UV ...

The present study is aimed at characterizing the landfill leachate as well as its impact on the surrounding groundwater in Kolkata, India. Landfill leachate has been seasonally characterized from 2012-2014, indicating the landfill site in methanogenic phase with high contamination of organics, nutrients, salts, and heavy metals. Sixty groundwater samples have been analyzed for twenty two physic...

Phytoplankton species composition as well as amount of Chlorophyll-a and their relation to physico-chemical parameters were studied. The samples were collected monthly from October 1996 until September 1997 in two stations, i.e. Lavan and Douberkeh coastal waters. In this study, 65 phytoplankton species related to 3 groups of diatoms, dinoflagellats and Blue-Green Algae (24 genus and 44 species...

The present study was designed to demonstrate the seasonal variations in physico-chemical parameters of fish farm at Govt. Nursery Unit, Muzaffargarh, Department of Fisheries Govt. of Punjab, Pakistan for a period of eight months from January to August 2008. Water samples were collected on fifteen days basis and have been analyzed for estimation of Air temperature, Water temperature, Light pene...

Runoff waters from a main bridge near Nantes (France), surface waters and pore waters in the infiltration basin collecting runoff were analysed after filtration and ultrafiltration to investigate the role of colloids in the transfer of trace metals (Zn, Cu and Pb) from the road to the groundwater. The role of the basin in mitigation of the variations of physico-chemical parameters and chemical ...

BACKGROUND Protein evolution is particularly shaped by the conservation of the amino acids' physico-chemical properties and the structure of the genetic code. While conservation is the result of negative selection against proteins with reduced functionality, the codon sequences determine the stochastic aspect of amino acid exchanges. Thus far, it is known that the genetic code is the dominant f...