The aim of this study was to investigate the antitumor activities of Phyllanthus amarus (PHA) and its potential of herb-drug interactions with 5-Fluorouracil (5-FU). Cell viability, ribonucleotides (RNs) and deoxyribonucleotides (dRNs) levels, cell cycle distribution, and expression of thymidylate synthase (TS) and ribonucleotide reductase (RR) proteins were measured with 3-(4,5-dimethylthiazol...

This study was conducted to evaluate the effects of herbal extracts on quality striped catfish (Pangasianodon hypophthalmus) fillets throughout storage period. Quality changes during ice were studied after dip treatments in aqueous solutions ethanolic extract Phyllanthus amarus (0.02% and 0.04%, w/v) or Euphorbia hirta (0.06% 0.02%, w/v). The control (dipped tap water) treated fish samples anal...

Background:Phyllanthus amarus (P. amarus) has been used as a medicinal plant for the prevention and treatment of chronic ailments such as diabetes, hepatitis, and cancer. Methods: The physicochemical properties, antioxidant and cytotoxic activities of crude extracts and fractions from P. amarus were determined using spectrophotometric method. Results: The P. amarus methanol (PAM) extract had lo...

Reactive oxygen species (ROS) such as superoxide radical anion, hydroperoxyl radical are generated in cells from byproducts of metabolism and responsible for the development of a wide number of degenerative diseases such as cardiovascular disease (CVD), diabetic, cirrhosis and several cancers1. All organisms have their own antioxidant defense system to protect them against free radical damage b...

Corresponding Author: Ashok D.B. Vaidya Kasturba Health Society, Advanced Centre of Reverse Pharmacology (ICMR) 17, Khandubhai Desai Road, Vile Parle (West), Mumbai, 400 056, India Email: [email protected] Abstract: The current scenario of drug discovery and development is facing a model perturbation, despite significant advances in genomics, proteomics, metabolomics, combinatorial chemistry and...

Nitrogen plays a pivotal role in growth and differentiation of cells of Phyllanthus amarus Schum. and Thonn. Both form and amount of nitrogen in nutrient medium have significant effects on the rate of cell growth and differentiation. In this study, effects of different inorganic nutrients (KNO3 and NH4NO3) and organic nutrients (glycine) on regeneration of P. amarus were evaluated. Murashige an...

Traditional Medicines derived from medicinal plants are used by about 60% of the world's population. This review focuses on Indian Herbal drugs and plants used in the treatment of diabetes, especially in India. Diabetes is an important human ailment afflicting many from various walks of life in different countries. In India it is proving to be a major health problem, especially in the urban are...