OBJECTIVE The study was divided into two parts. The objective of the preliminary study was to evaluate the optimum dose and tolerance of 5-aminolaevulinic acid (5-ALA) compared to a placebo cream with a 633-nm LED light in normal, healthy, volunteer forearm skin. The second study was to establish if ALA-PDT treatments improve the signs of ageing. RESULTS Threshold photosensitization was obser...

The purpose of this study was to evaluate the prevalence of sunscreen contact allergy and/or contact photoallergy in 370 patients with suspected photodermatitis. Patch and photopatch tests were performed using the French Society of Photodermatology (SFPD) standard series. A total of 57 cases of contact allergy and/or photocontact allergy to sunscreens were diagnosed (15.4%). Amongst these, 27 r...

The formation of Thy-Thy in DNA in the presence of tyramine, tyrosine and tyrosine-containing peptides such as Lys-Tyr and Lys-Tyr-Lys was studied with monochromatic UV irradiation. The formation of Thy-Thy by UV irradiation was enhanced in the presence of these compounds. The action spectrum of the photosensitization has a peak near 280 nm corresponding to the absorption spectrum of tyrosine. ...

The synthesis and photophysical properties of new multiporphyrin assemblies are described. Their design, based on a smooth electronic disconnection between two-photon absorbing (2PA) octupolar or quadrupolar cores and the peripheral porphyrins, leads to a major increase in (non-resonant) 2PA responses in the NIR, while fully retaining the fluorescence and photosensitization properties of isolat...