Targeted maximum likelihood estimation (TMLE) is a general method for estimating parameters in semiparametric and nonparametric models. The key step in any TMLE implementation is constructing a sequence of least-favorable parametric models for the parameter of interest. This has been done for a variety of parameters arising in causal inference problems, by augmenting standard regression models ...

The paper titled " Primary Small Cell Undifferentiated (Neuroendocrine) Carcinoma of the Maxillary Sinus " [1], published in Case Reports in Dentistry, has been retracted as it was submitted without the knowledge or consent of coauthor Dr. Premalatha Shetty who was responsible for the patient whose case was presented in the manuscript.

BACKGROUND Lao PDR is a low-income country with an urgent need for evidence-informed policymaking in the healthcare sector. During the last decade a number of Health Systems Research (HSR) projects have been conducted in order to meet this need. However, although knowledge about research is increasing among policymakers, the use of research in policymaking is still limited. METHODS This artic...

Professional development (PD) is essential for primary school teachers to meet the demands of the education system. Quality PD is aligned with classroom conditions, school contexts and teachers’ daily experiences. The purpose of the study was to explore primary teachers’ experiences of a 6-week physical education professional development programme (PE-PDP). A single school case study was employ...

PPE represent a peculiar family of mycobacterial proteins characterized by a 180 aminoacids conserved N-terminal domain. Several PPE genes are co-transcribed with a gene encoding for a protein belonging to another family of mycobacterial specific proteins named PE. Only one PE-PPE couple has been extensively characterized so far (PE25-PPE41) and it was shown that these two proteins form a heter...

Transmission constraints in electric networks can limit competition and create pockets of local market power. The policy response to this reality includes many elements ranging from special contracting arrangements to divestiture of assets. Although a full analysis of the impacts of local market power is complex and context specific, there are some general principles that can guide the discussion.

We propose an efficient methodology for comparing computational models of a perceptually discriminable quantity. Rather than comparing model responses to subjective responses on a set of pre-selected stimuli, the stimuli are computer-synthesized so as to optimally distinguish the models. Specifically, given two computational models that take a stimulus as an input and predict a perceptually dis...

Because some of the decline in strength with age may be explained by an impairment of muscle activation, the purpose of this study was to determine the activation level achieved in biceps brachii by older adults during a maximum voluntary contraction (MVC). This capability was assessed with two superimposition techniques: one calculated the activation level that was achieved during an MVC, and ...