In medical contexts, the word "phenotype" is used to refer to some deviation from normal morphology, physiology, or behavior. The analysis of phenotype plays a key role in clinical practice and medical research, and yet phenotypic descriptions in clinical notes and medical publications are often imprecise. Deep phenotyping can be defined as the precise and comprehensive analysis of phenotypic a...

 Research priorities in bronchiectasis: a consensus statement from the EMBARC Clinical Research Collaboration Stefano Aliberti, Sarah Masefield, Eva Polverino, Anthony De Soyza, Michael R. Loebinger, Rosario Menendez, Felix C. Ringshausen, Montserrat Vendrell, Pippa Powell, James D. Chalmers http://erj.ersjournals.com/content/48/3/632.long Please remember to visit the EMBARC homepage for links...

Phenotypes have gained increased notoriety in the clinical and biological domain owing to their application in numerous areas such as the discovery of disease genes and drug targets, phylogenetics and pharmacogenomics. Phenotypes, defined as observable characteristics of organisms, can be seen as one of the bridges that lead to a translation of experimental findings into clinical applications a...

Drought has emerged as one of the major constraints in banana production. Its effects are pronounced substantially in the tropics and sub-tropics of the world due to climate change. Bananas are quite sensitive to drought; however, genotypes with "B" genome are more tolerant to abiotic stresses than those solely based on "A" genome. In particular, bananas with "ABB" genomes are more tolerant to ...

18 19 The 3T3-L1 murine cell line is a robust and widely used model for the study of 20 adipogenesis and processes occurring in mature adipocytes. The fibroblastic like cells 21 can be induced by hormones to differentiate into mature adipocytes. In this study, the 22 metabolic phenotype associated with differentiation of the 3T3-L1 cell line has been 23 studied using gas chromatography-mass spe...

Low back pain (LBP) is the world's most disabling condition. Modic changes (MC) are vertebral bone marrow changes adjacent to the endplates as noted on magnetic resonance imaging. The associations of specific MC types and patterns with prolonged, severe LBP and disability remain speculative. This study assessed the relationship of prolonged, severe LBP and back-related disability, with the pres...

Objectives: Given the quickening speed of discovery of variant disease drivers from combined patient genotype and phenotype data, the objective is to provide methodology using big data technology to support the definition of deep phenotypes in medical records. Methods: As the vast stores of genomic information increase with next generation sequencing, the importance of deep phenotyping increase...

Employing multiple advanced technologies offers an approach for identifying and phenotyping circulating tumor cells in blood samples.

Abstract Modeling passive data collected by smartphones, or digital phenotyping, may help detect the early signs of declines in daily health and lead to steps prevent declines. Health-related outcomes have been typically acquired through self-report measures, however this broad approach has several limitations, such as recall social desirability bias. A potential solution is phenotyping. Guided...