To investigate the role of vasculature in pancreatic ?-cell regeneration, we crossed a zebrafish ablation model into avascular npas4l mutant (i.e. cloche ). Surprisingly, regeneration increased markedly mutants owing to ectopic differentiation ?-cells mesenchyme, phenotype not previously reported any models. The expressed endocrine markers ?-cells, and also responded glucose with calcium influx...

Developmental phenotypic plasticity is a widespread phenomenon that allows organisms to produce different adult phenotypes in response environments. Investigating the molecular mechanisms underlying has potential reveal precise changes lead evolution of as phenotype. Here, we study wing multiple host?plant adapted populations pea aphids model for understanding adaptation environments within sin...

Classical tissue recombination experiments have reported that at early gestation both tracheal and distal lung epithelium have the plasticity to respond to mesenchymal signals. Herein we examined the role of epithelial-mesenchymal interactions in maintaining epithelial differentiation at late (E19-E21, term = 22 days) fetal gestation in the rat. Isolated distal lung epithelial cells were recomb...

Combined loss of tumor suppressors (TSPs), PTEN, TP53, and RB1, is highly associated with small cell carcinoma of prostate phenotype. Recent genomic studies of human tumors as well as analyses in mouse genetic models have revealed a unique role for these TSPs in dictating epithelial lineage plasticity-a phenomenon that plays a critical role in the development of aggressive variant prostate canc...

Aggressive tumor cells express a plastic, multipotent phenotype similar to embryonic stem cells. However, the absence of major regulatory checkpoints in these tumor cells allows aberrant activation of embryonic signaling pathways, which seems to contribute to their plastic phenotype. Emerging evidence showing the molecular cross-talk between two major stem cell signaling pathways Nodal and Notc...

The endometrium is central to mammalian fertility. The endometrial stromal cells are very dynamic, growing and differentiating throughout the estrous cycle and pregnancy. In humans, stromal cells appear to have progenitor or stem cell capabilities and the cells can even differentiate into bone. It is not clear whether bovine endometrial stromal cells exhibit a similar phenotypic plasticity. So,...

The killifish Fundulus heteroclitus is an estuarine species with broad physiological plasticity, enabling acclimation to diverse stressors. Previous work suggests that freshwater populations expanded their physiology to accommodate low salinity environments; however, it is unknown whether this compromises their tolerance to high salinity. We used a comparative approach to investigate the mechan...

statement of problem: low- fusing compound (type 1) is used for border molding and impressions. flow and reproducibility of surface detail are two important characteristics of these materials. there are no valid data available comparing domestic and imported brands. purpose: the purpose of this study was to evaluate these two properties of four different products including kerr (kerr manufactur...

Aerobic glycolysis, also referred to as the Warburg effect, has been regarded as the dominant metabolic phenotype in cancer cells for a long time. More recently, it has been shown that mitochondria in most tumors are not defective in their ability to carry out oxidative phosphorylation (OXPHOS). Instead, in highly aggressive cancer cells, mitochondrial energy pathways are reprogrammed to meet t...