Enantiomer separation represents an important topic especially in pharmaceutical and environmental fields where many drugs and pesticides are racemic compounds. In some cases, only one of the enantiomers has pharmacological or pesticidal activity while the other may exhibit antagonistic activities, unwanted side effects or even toxic effects. Therefore, the development of new enantioseparation ...

PURPOSE To report successful combined percutaneous mechanical thrombectomy and pharmacological lysis for axillosubclavian vein thrombosis, with rapid clot removal at a single setting using low-dose thrombolysis. CASE REPORTS Two consecutive patients presented with arm swelling; the diagnosis of axillosubclavian vein thrombosis was confirmed with duplex ultrasound. Both patients were treated p...

Midazolam is a short-acting benzodiazepine that is widely used in anesthesia. Despite its widespread clinical use, detailed information about cardiac side effects of midazolam is largely lacking. Using the double-electrode voltage clamp technique, we studied pharmacological effects of midazolam on heterologously expressed Kv1.5 channels underlying atrial repolarizing current I(Kur). Midazolam d...

Whole-cell patch neurophysiology and pharmacological manipulations have provided unprecedented insight into the functions of central neurons, but their combined use has been largely restricted to in vitro preparations. We describe a method for performing whole-cell patch recording and focal application of pharmacological agents in vivo. A key feature of this technique involves iontophoresis of ...

Globally HIV/AIDS raised as a biggest health problem. Normally only pharmacological techniques are using for controlling HIV/AIDS symptoms. But some alternative techniques are also available which can control major psychological symptoms like anxiety and depression in HIV/AIDS patients. Present meta analysis emphasis effect of those alternative techniques hypnotherapy and Jacobson progressive m...

Recent studies using chemiluminescence and spectrophotometry have shown that cultured and native endothelial cells release nitric oxide (NO). Pharmacological and biochemical evidence argue for and against the proposal that endothelium-derived relaxing factor (EDRF) is identical with free NO. In an attempt to identify EDRF as free NO, a bioassay technique was combined with an NO trap (hemoglobin...

Background: Labor pain is among the foremost severe that ladies experience in their lifespan, if inadequately treated can lead to certain complications labor. Relieving this with medical interventions also full of misconceptions and disagreement people. Different traditional pharmacological methods for labor relief are utilized by obstetric care providers. Aims Objectives: The aim study was obt...

The characterization of pharmacological properties from their chemical structure has become a challenging and promising technique in computer aided drug design. The idea consists of finding appropriate representations of candidate compounds in terms of their chemical formulae and try to apply a particular machine learning method able to appropriately characterize certain desired properties or k...

Objective: To discuss the results of chiropractic care in a 19 month-old patient with the diagnosis of severe chronic asthma and vertebral subluxation. Clinical Features: This patient began experiencing symptoms at age 9 months. By age 18 months he had been treated 4 times at the hospital emergency room for episodes of acute respiratory distress. He suffered from constant wheezing and cough and...

Interstitial cells of Cajal (ICCs) are the pacemaking cells in the gastrointestinal muscles that generate the rhythmic oscillations in membrane potential known as slow waves. ICCs also mediate or transduce inputs from the enteric nervous system. Substance P (SubP) is a member of the family of mammalian tachykinin peptides that are predominantly released by enteric neurons. This study assessed t...