Blunted neuroendocrine and physiological responses to the selective 5-HT(1A) receptor agonist, ipsapirone, have been observed in patients with panic disorder and/or agoraphobia (PDA). In order to examine whether this hyporesponsiveness to ipsapirone is modified by pharmacological or non-pharmacological therapeutic interventions, challenges with an oral dose of ipsapirone (0.3 mg/kg) and placebo...

The development of pharmacological magnetic resonance imaging (phMRI) has presented the opportunity for investigation of the neurophysiological effects of drugs in vivo. Psilocin, a hallucinogen metabolised from psilocybin, was recently reported to evoke brain region-specific, phMRI signal changes in humans. The present study investigated the effects of psilocin in a rat model using phMRI and t...

More and more people are concerned by the risk of unexpected side effects observed in the later steps of the development of new drugs, either in late clinical development or after marketing approval. In order to reduce the risk of the side effects, it is important to look out for the possible xenobiotic responses at an early stage. We attempt such an effort through a prediction by assuming that...

Peripheral chemoreceptors located in the carotid bodies are the primary sensors of systemic hypoxia. Although the pattern of responses elicited by peripheral chemoreceptor activation is well established in rats, lambs, and rabbits, the cardiovascular responses to peripheral chemoreflex activation in conscious mice have not been delineated. Here we report that stimulation of peripheral chemorece...

Oncolytic viruses (OVs) not only kill cancer cells by direct lysis but also generate a significant anti-tumor immune response that allows for prolonged cancer control and in some cases cures. How to best stimulate this effect is a subject of intense investigation in the OV field. While pharmacological manipulation of the cellular innate anti-viral immune response has been shown by several group...

Multimodal analgesia captures the effectiveness of individual agents in optimal dosages that maximize efficacy and attempts to minimize side effects from one analgesic (mainly opioids). This important concept employs the theory that agents with different mechanisms of analgesia that may have synergistic effects in preventing or treating acute pain when used in combination. These regimens must b...

BACKGROUND Current rodent models emphasize the joint action of the stress mediators noradrenaline (NE) and cortisol (CORT) in conferring a memory advantage of emotional over neutral stimuli. METHOD Using a pharmacological strategy of tackling this stress-related mechanism to enhance human episodic (autobiographical) memory, we measured amygdala-hippocampal responses during encoding of emotion...

The difficulty of accurately localizing the source of subjective tinnitus is well-known. Anamnesis and traditional audiological tests can often suggest a source if its origin as peripheral or merely central (or both). Therefore, several authors, such as Risey, Denk, and Shulman, recently proposed identifying the source of subjective tinnitus through the evaluation of the responses reported by p...

Two studies are reported in which the threshold estimates from auditory steady-state response (ASSR) tests are compared to those of click- or toneburst-evoked auditory brainstem responses (ABRs). The first, a retrospective review of 51 cases, demonstrated that both the click-evoked ABR and the ASSR threshold estimates in infants and children could be used to predict the pure-tone threshold. The...

The feasibility of recording bone-conducted auditory brainstem responses (ABRs) to 500-Hz and 2000-Hz tone bursts and clicks was investigated in normal-hearing adults. For all 3 stimuli, responses were detectable in all subjects at 30 dB nHL. At 20 dB nHL, the tone burst responses were detectable in 80-87% of the subjects, demonstrating that even the responses to 500-Hz tone bursts were relativ...