Many essential oils and monoterpenes are used therapeutically as relaxing drugs and tranquilizers. In this study, ten structurally related monoterpene alcohols, present in many essential oils, were evaluated in mice to investigate their pharmacological potential in the central nervous system. Isopulegol (1), neoisopulegol (2), (+/-)-isopinocampheol (3), (-)-myrtenol (4), (-)-cis-myrtanol (5), (...

The cardiovascular activity of essential oils has been reported. Some studies showed that the main chemical components of these oils contribute to their pharmacological activity. Therefore, the cardiovascular activity of four monoterpenes and one sesquiterpene was evaluated in the present work. In non-anaesthetized normotensive rats, (+)-alpha-pinene, (-)-beta-pinene, (+/-)-citronellol and (+/-...

chemical structure. The pharmacological studies on SIN-10 by Takenaka et al. (2) showed a sustained hypotensive effect in rabbits. The similar effect was also confirmed in the dog, cat and rat by Kikuchi et al. (3). In order to provide a biochemical basis for the pharmacological and toxicological mechanisms, the metabolic aspects of SIN-10 have been studied in rats and mice. The present paper d...

The association between hormone replacement therapy (HRT) and breast cancer has been debated since the introduction of this treatment. Recently, the WHI study and the Million Women Study confirmed the direct relation between HRT and the increase of breast cancer risk. These findings strongly emphasize the need for a safe and effective alternative treatment for the management of menopause. In pr...

The natural products extracted from plants are part of traditional medicine and also therapeutic possibilities for treating many diseases. Recently, its use in the development new drugs has shown much visibility efficiency few adverse effects. Essential oils medicinal indicated to treat numerous diseases due their antimicrobial, antiviral, antimutagenic, anticancer, antioxidant, anti-inflammato...

Background: Schizophrenia is a devastating psychiatric disorder and its  Positive and negative symptoms have negative effects on social functions. A combination of pharmacological and non-pharmacological treatments is considered more effective for this condition. The present study aimed to determine the effect of a group horticulture program on psychiatric symptoms in patients with chronic...

advances in understanding the neurobiology of addiction to stimulants, has made it possible for researchers to identify medicines effective in initiation of treatment and prevention of stimulants relapse, based on pharmacological effects of various medicine. some of these medicine and vaccines have brought promising results in clinical trials on cocaine dependent patients. studies regarding met...

background and objective: considering the wide side effects of synthetic pain killers, use of herbal drugs in folk medicine as analgesic agents has increased. in the present work, we tried to uncover the pharmacological potential of ethanolic extracts by using various animal models and also to explore the potent antinociceptive effect of the plant thymus kotschyanus. materials and methods: the ...

the aim of this research was to investigate the cyclooxygenase-2 (cox-2) selective inhibition effect on haloperidol-induced catatonia. in this study, the effect of orally, acutely and sub-chronically administrations of compound 11b [1-(phenyl)-5-(4-methylsulfonylphenyl)-2-ethylthioimidazole] (2, 4 and 8 mg/kg), a newly selective cox-2 inhibitor, was investigated against the haloperidol-induced ...