Abstract Ibrutinib is a drug used for the treatment of marginal zone lymphoma, mantle cell lymphocytic leukemia, chronic graft, and Waldenstrom macroglobulinemia. A simple, sensitive, fast liquid chromatographic spectrophotometric method quantification ibrutinib in pharmaceutical forms bulk was developed validated. The technique using an ODS 3 C 18 (250 mm × 4.6 i.d., 5 µm) column. mobile phase...