Many potential neurotoxins exist and are classified (1-7) as: 1) pharmaceutical agents, 2) biological agents, 3) radiation and electricity, 4) heavy metals, 5) solvents and vapors, 6) insecticides, herbicides, fungicides, and rodenticides, 7) air pollution, 8) food additives, 9) social poisons. The reader is referred to sources of toxicology information available on the internet (6, 7). These i...

The specter of antibiotic-resistant bacteria has provoked renewed interest in the possible use of bacteriophages to control bacterial infections. We argue that clinical application of phage therapy has been held back by a failure to appreciate the extent to which the pharmacokinetics of self-replicating agents differ from those of normal drugs. For self-replicating pharmaceutical agents, treatm...

Target-specific delivery of diagnostic and/or therapeutic agents has become a main concern in the research of nanomedicine and in the pharmaceutical industry. Formulation of targeting effects can deliver high dose of the formulated diagnostic/therapeutic agents specifically to the diseased cells and leave the healthy cells untouched, which can thus result in much higher diagnostic/therapeutic e...

The vast majority of all agents used to directly kill cancer cells (ionizing radiation, most chemotherapeutic agents and some targeted therapies) work through either directly or indirectly generating reactive oxygen species that block key steps in the cell cycle. As mesenchymal cancers evolve from their epithelial cell progenitors, they almost inevitably possess much-heightened amounts of antio...

The development of antimicrobial agents represents one of the most significant achievements in medicine during the past century. However, the emergence of antimicrobial resistance combined with the downturn in the development of new antimicrobial agents in the pharmaceutical industry poses unanticipated challenges in the effective management of infection. The issue of how we can most effectivel...

The pharmaceutical production industries generate wastewaters that should be properly treated because in some cases they are highly toxic. For this reason the safe inactivation before disposing them into the environment must be guarantee. This paper deals with an ozone treatment system for the wastewaters generated in the cytostatic production. The cytostatics present in the wastewaters treatme...

PURPOSE Treatment of hypertension is expensive and cost is one of the reasons for inadequate blood pressure control. Where there are no social cost cushions, the burden is borne by patients. With pervasive poverty and inadequate control, complications are unchecked. Back titration in appropriate circumstances should, therefore, translate to economic benefit. This is an attempt to compute, in ec...

OBJECTIVE To analyze the profile of claimants and medicines demanded in lawsuits. METHODS Descriptive study that examined 827 lawsuits with 1,777 demands of access to medicines in the period between July 2005 and June 2006 in the state of Minas Gerais, Southeastern Brazil. There were examined the type of health care provided to claimants and their attorneyship. The medicines were described ba...

BACKGROUND Patients commonly experience palpable effects from antihypertensives. Few studies have examined patients' experiences of these effects and how they influence patients' behaviour and medicine-taking. OBJECTIVES To describe the palpable effects that patients attribute to their antihypertensive tablets and the ways that they react to them. METHODS In depth interviews with a maximum ...

We here introduce octahedral silicon serving as a structural center for the design of hydrolytically stable bioactive complexes as demonstrated with the generation of silicon-based high affinity DNA binders. This proof-of-principle study suggests that octahedral silicon complexes are falsely neglected, promising structural templates for widespread applications in chemical biology and medicinal ...