Our interest in prostaglandins (PGs) as antitumor agents stemmed from the report of Bregman and Meyskens (Cancer Res., 43: 1642-1645, 1983) that PGA1, PGA2, and PGD2 inhibited colony formation by human melanoma cells obtained from fresh biopsies of melanoma patients. We tested several PGs and found that PGA1, PGA2, and PGD2 were the most cytotoxic to L1210 cells in culture. Therefore, we studie...

Serglycin (SG) proteoglycans (PG) are predominantly located intracellularly in secretory vesicles of hematopoietic cells such as macrophages, cytotoxic T lymphocytes (CTLs), monocytes, basophils, neutrophils and mast cells (MCs). These PGs are characterized by their protease-resistant serine and glycine-rich core and also by their covalently attached negatively charged glycosaminoglycans (GAG) ...

Prostaglandins (PGs), produced by two isoforms of cyclooxygenase (COX), COX-1 and COX-2, are important modulators of renal hemodynamics. COX-1 and COX-2 are expressed in the kidney often at distinct sites. Thromboxane (TxA(2)), PGE(2), and prostacyclin (PGI(2)) are the major PGs in the renal cortex of mice. Acute infusion of the vasoconstrictor ANG II increases COX-2-dependent PGE(2) and PGI(2)...

This study investigates postgraduate (PGs) and faculty needs concerning academic writing (AW) tutors’ qualifications in an English as a Foreign Language (EFL) context. Tutors are the core element of center (WC) (Hays, 2010). These professionals listen to (Burns, 2014), advise, exchange information (Reid, 1993, Hays, 2010) collaboratively so students can resolve their issues However, EFL context...

Devascularization of the parathyroid glands (PGs) during total thyroidectomy (TT) is cause post-surgical parathyroprival hypocalcemia. Safeguarding anatomical integrity and vascularity PGs primarily requires an experienced surgeon. The combined use magnification loupes (2.5× or 3.5×) with ultrasound/radiofrequency device bipolar forceps also helpful. Near-infrared autofluorescence imaging may p...

Proteoglycans (PGs) synthesized by chick corneal stromal cells in cell culture and organ culture were metabolically radiolabelled with [35S]sulfate (for glycosaminoglycans) and [3H]leucine (for core proteins). Media, cell extracts and organ extracts from cultures were chromatographed on DEAE-Sephacel columns and separated into three fractions: the pass-through fraction (Fraction 1: nonsulfated ...

We investigate the dynamics of and the relations between small-scale penumbral and photospheric features near the outer penumbral boundary: penumbral grains (PGs), dark penumbral fibrils, granules, and photospheric G−band bright points. The analysis is based on a 2 h time sequence of a sunspot close to disc center, taken simultaneously in the G−band and in the blue continuum at 450.7 nm. Observ...

Cellular and extracellular (tubular basement membrane, TBM) alterations in the proteoglycans (PGs) of the rat renal tubules in diphenylthiazole-induced cystic disease were investigated. The PGs of normal and cystic kidneys were labeled with [35S]sulfate in an organ-perfusion system. Extracted cellular and TBM PGs were characterized by Sepharose CL-6B chromatography before or after treatment wit...