Study of the afferents of the rat globus pallidus (GP) with Fluoro-gold, a retrograde tracer, revealed retrogradely labeled neurons in the ipsilateral parafascicular nucleus of the thalamus (PF), a previously undescribed afferent of the rat GP. We used the anterograde tracer, Phaseolus vulgaris-leucoagglutinin (PHA-L), to confirm and extend our findings. After injections of PHA-L in the PF, lab...

We conducted a controlled clinical comparison of PF Plus, the new pediatric medium with adsorbent polymeric beads, versus the charcoal-containing PF medium in the BacT/Alert blood culture system. A total of 2,381 pediatric cultures were enrolled, and 1,703 (71.5%) were deemed to be compliant and acceptable for analysis. Seventy-two cultures (4.2%) had a positive result with 80 clinically signif...

Abstract Plasmodium spp. cause more than half a million malaria deaths annually and the only approved vaccine, RTS,S, based on P.falciparum (Pf) circumsporozoite protein (CSP), confers incomplete non-durable protection. A strategy to improve vaccines involves combining Ags of different stages such as sporozoite (spz) liver stage (LS). This promises broader repertoire specific antibodies (Ab), C...

Paeoniflorin (PF) is an active monoterpene glycoside extracted from Paeonia lactiflora Pall. PF has exhibited antitumor effects in various cancer types. However, the effects of PF in pancreatic cancer are largely unexplored. Here, we showed that PF suppressed growth of pancreatic cancer cell lines Capan-1 and MIAPaCa-2 and profoundly sensitized these cells to X-ray irradiation. Through microarr...

ISSN 0973-2063 Bioinformation 1(9): 351-355 (2007) www.bioinformation.net Given f:R(A1, ...,An)→Y and S ⊆ Y, the (uncompressed, single node-level) Predicate-tree Pf, S is the bitmap, Pf,S(x)=1 (i.e., true) iff f(x)∈S, ∀x∈R. Note that Pf,S bitmaps the set, F-contour({1}) under the function, F(x) = 1 if f(x)∈S else F(x)=0. In Mathematical terms, F is the Characteristic function of the contour, f(...

Background Pulmonary fibrosis (PF) is an increasing cause of morbidity and mortality with five million people affected worldwide and a median survival time of less than three years. Effective anti-fibrotic agents for PF are currently lacking. The majority of patients with PF develop pulmonary hypertension (PH) and right heart failure. Impaired production of endogenous nitric oxide (NO) plays an...

The highly specific relationships between parallel fiber (PF) and climbing fiber (CF) receptive fields in Purkinje cells and interneurons suggest that normal PF receptive fields are established by CF-specific plasticity. To test this idea, we used PF stimulation that was either paired or unpaired with CF activity. Conspicuously, unpaired PF stimulation that induced long-lasting, very large incr...

Pemphigus foliaceus (PF) is a human autoimmune disease in which antibodies are directed against the cell surface of epidermal cells with resultant blister formation. The histopathology of these blisters indicates that cells have detached from each other, and electron microscopy of early blisters shows diminished numbers, to complete loss, of desmosomes as well as abnormalities of the tonofilame...

Two simple complexes [Pt(phen)(2)](PF(6))(2) and [Pt(bpy)(2)](PF(6))(2) exhibit high stabilization potential for G-quadruplex DNA with [Pt(phen)(2)](PF(6))(2) possessing higher capability due to its greater planarity.

BACKGROUND Chance imbalance in baseline prognosis of a randomized controlled trial can lead to over or underestimation of treatment effects, particularly in trials with small sample sizes. Our study aimed to (1) evaluate the probability of imbalance in a binary prognostic factor (PF) between two treatment arms, (2) investigate the impact of prognostic imbalance on the estimation of a treatment ...