Peters Plus syndrome (PPS), a congenital disorder of glycosylation, results from recessive mutations affecting the glucosyltransferase B3GLCT, leading to congenital corneal opacity and diverse extra-ocular manifestations. Together with the fucosyltransferase POFUT2, B3GLCT adds Glucoseβ1-3Fucose disaccharide to a consensus sequence in thrombospondin type 1 repeats (TSRs) of several proteins. Wh...

Differentiating demyelinating conditions from neoplastic conditions can pose a significant challenge. There are a number of reports in the literature of large ring-enhancing, space-occupying lesions that were initially considered neoplastic or infectious but, on further review, were deemed demyelinating. Creutzfeldt-Peters cells (CPC) are reactive astrocytes with fragmented nuclear inclusions t...

During the 1990’s various fish stocks in the Columbia Basin were listed as threatened or endangered under the U.S. Endangered Species Act (ESA) (NMFS 1995, 2000, Lohr et al. 2001). These listings included sockeye, spring/summer Chinook, fall Chinook, steelhead and bull trout. My perspective on the ESA is a function of four sets of related experiences over the last decade, all of which have invo...

A bench study followed by a clinical trial were performed to evaluate the mechanical characteristics of five (commercially available) expiratory valves used for home ventilators, as well as the potential clinical impact of differences between these valves. In the in vitro study, expiratory valve resistance was evaluated under unvarying conditions, whereas dynamic behaviour was evaluated by calc...

Gravitational wave detection experiments in space, including satellite Doppler-Tracking (Bertotti and Iess, 1999) and LISA (http://lisa.jpl.nasa.gov), will hopefully open a window on the low-frequency part of the gravitational wave (henceforth GW) spectrum of cosmic origin. In these frequency bands, binary stars are among the most promising continuous detectable source. A substantial fraction o...

Fluoroacetate is a potent poison of animals. It is metabolized to fluorocitrate, which is a powerful inhibitor of mammalian aconitate hydratase [aconitase; citrate (isocitrate) hydrolyase] (Peters, 1952). Fluoroacetate and fluoroacetamide, as systemic insecticides for plants, are taken up by the roots or absorbed by the leaves and are then translocated to other parts of the plant. The plants sh...

Thiamin, acting in the form of its phosphoric ester co-carboxylase, is an enzyme necessary for the complete metabolism of glucose. In its absence glucose is broken down as far as pyruvic acid, which then accumulates until vitamin B1 is supplied. Peters and Thompson (1934) and Peters (1936) demonstrated that the respiration of avitaminotic pigeon brain was reduced as compared with that of normal...