OBJECTIVES Early therapy improves outcomes in rheumatoid arthritis (RA). It is therefore important to improve predictive algorithms for RA in early disease. This study evaluated musculoskeletal ultrasound, a sensitive tool for the detection of synovitis and erosions, as a predictor of outcome in very early synovitis. METHODS 58 patients with clinically apparent synovitis of at least one joint...

Objectives To describe the diagnostic spectrum, arthritis persistency and clinical outcomes after 2 years in patients with inflammatory arthritis (IA) of less than 16 weeks' duration. Methods Data from the Norwegian Very Early Arthritis Clinic, a 2-year longitudinal observational study of adults with IA of ≤16 weeks' duration, were used. Exclusion criteria were arthritis due to crystal deposi...

In this study we prepared YxYb1-xBa2Cu3O7-δ (x = 0.1, 0.2, 0.3, 0.4, 0.5) powders and bulks to use as intermedium for superconducting joint between REBCO-coated conductors. Superconducting joints are essential in the development of high-field REBCO persistent magnets. All were sintered at 850 °C 10 hours air. Bulks by pressing 70 MPa. Calcination was performed under same conditions powders. Two...

Proinflammatory cytokines are major mediators in the pathogenesis of diseases of joints such as rheumatoid arthritis and osteoarthritis. This review emphasizes that proinflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-17 are also mediators of pain by directly acting on the nociceptive system. Proportions of nociceptive sensory neurons ...

BACKGROUND DNA CpG methylation is carried out by DNA methyltransferases and induces chromatin remodeling and gene silencing through a transcription repressor complex comprising the methyl-CpG-binding protein 2 (MeCP2) and a subset of histone deacetylases. Recently, we have found that MeCP2 activity had a crucial role in the pattern of gene expression seen in the superficial dorsal horn rapidly ...

abstract introduction: in this study the role of pge2 as an important inflammatory mediator in indomethacine and theophylline effects on joint diameter and vascular response of chronically inflamed rat knee joint to saphenous nerve stimulation was investigated. methods: inflammation was induced by intraarticular injection of 0.2 ml freund,s complete adjuvant (fca) and 3, 7, 14, 21 days post inj...