نتایج جستجو برای: peroxynitrite

تعداد نتایج: 3024  

Journal: :American journal of physiology. Heart and circulatory physiology 2002
Tamás Csont Csaba CsonkA Annamária Onody Anikó Görbe László Dux Richard Schulz Gary F Baxter Péter Ferdinandy

Clinical studies have suggested that long-term nitrate treatment does not improve and may even worsen cardiovascular mortality, and the possible role of nitrate tolerance has been suspected. Nitrate tolerance has been recently shown to increase vascular superoxide and peroxynitrite production leading to vascular dysfunction. Nevertheless, nitrates exert direct cardiac effects independent from t...

Journal: :Nucleic acids research 1996
B Epe D Ballmaier I Roussyn K Briviba H Sies

The DNA damage induced by peroxynitrite in isolated bacteriophage PM2 DNA was characterized by means of several repair enzymes with defined substrate specificities. Similar results were obtained with peroxynitrite itself and with 3-morpholinosydnonimine (SIN-1), a compound generating the precursors of peroxynitrite, nitric oxide and superoxide. A high number of base modifications sensitive to F...

2002
Zarema Balafanova Roberto Bolli Jun Zhang Yuting Zheng Jason M. Pass Aruni Bhatnagar Xian-Liang Tang Ouli Wang Peipei Ping

Activation of protein kinase C (PKC) by nitric oxide (NO) has been implicated in the development of cardioprotection. However, the cellular mechanisms underlying the activation of PKC by NO remain largely unknown. Nitration of protein tyrosine residues has been shown to alter functions of a variety of proteins, and NO-derived peroxynitrite is known as a strong nitrating agent. In this investiga...

Journal: :American journal of physiology. Cell physiology 2000
S Zhuang G Simon

In this study, we show that caspases 2, 3, 6, and 7 were activated during peroxynitrite-induced apoptosis in human leukemia HL-60 cells and that processing of these caspases was accompanied by cleavage of poly(ADP-ribose) polymerase and lamin B. Treatment of cells with DEVD-fluoromethyl ketone (FMK), a selective inhibitor for caspase 3-like proteases, resulted in a marked diminution of apoptoti...

Journal: :Cardiovascular research 2003
Hae-Young Sohn Florian Krotz Stefan Zahler Torsten Gloe Matthias Keller Karl Theisen Thomas M Schiele Volker Klauss Ulrich Pohl

INTRODUCTION AND METHODS The reaction of superoxide anions and NO not only results in a decreased availability of NO, but also leads to the formation of peroxynitrite, the role of which in the cardiovascular system is still discussed controversially. In cultured human endothelial cells, we studied whether there is a significant interaction between endothelial NO and neutrophil-derived superoxid...

2012
Mark J. Kohr Steve R. Roof Jay L. Zweier Mark T. Ziolo

Peroxynitrite is a potent oxidant that is quickly emerging as a crucial modulator of myocardial function. This review will focus on the regulation of myocardial contraction by peroxynitrite during health and disease, with a specific emphasis on cardiomyocyte Ca(2+) handling, proposed signaling pathways, and protein end-targets.

Journal: :Epilepsia 2009
Yao-Chung Chuang Shang-Der Chen Chia-Wei Liou Tsu-Kung Lin Wen-Neng Chang Samuel H H Chan Alice Y W Chang

PURPOSE One cellular consequence of status epilepticus is apoptosis in the hippocampal CA3 subfield. We evaluated the hypothesis that the repertoire of cellular events that underlie such elicited cell death entails mitochondrial dysfunction induced by an excessive production of nitric oxide synthase II (NOS II)-derived NO, increased superoxide anion (O(2)(-)) production, and peroxynitrite forma...

Journal: :Journal of cell science 2012
Mohammed A Abdelsaid Azza B El-Remessy

Although promising, the ability to regulate angiogenesis through delivery of VEGF remains an unrealized goal. We have shown previously that physiological levels of peroxynitrite (1 µM) are required for a VEGF-mediated angiogenic response, yet the redox-regulated mechanisms that govern the VEGF signal remain unexplored. We assessed the impact of VEGF and peroxynitrite on modifying redox-state, t...

Journal: :Cardiovascular research 2010
Sowndramalingam Sankaralingam Han Xu Sandra T Davidge

AIMS Preeclampsia is a hypertensive disorder characterized by vascular oxidative stress. Decreased availability of the vasodilator nitric oxide (NO) has been postulated to be involved in the pathophysiology of this disorder. Arginase, an enzyme that competes with nitric oxide synthase (NOS) for l-arginine, not only reduces NO formation but also increases superoxide production by NOS. In placent...

Journal: :The Journal of biological chemistry 2003
Hao Zhang Kalpana Bhargava Agnes Keszler Jimmy Feix Neil Hogg Joy Joseph B Kalyanaraman

We have shown previously that peroxynitrite-induced nitration of a hydrophobic tyrosyl probe is greater than that of tyrosine in the aqueous phase (Zhang, H., Joseph, J., Feix, J., Hogg, N., and Kalyanaraman, B. (2001) Biochemistry 40, 7675-7686). In this study, we have tested the hypothesis that the extent of tyrosine nitration depends on the intramembrane location of tyrosyl probes and on the...

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