OBJECTIVES The aim of this study was to determine the protective mechanisms of wild ginseng cambial meristematic cells (CMCs) on non-alcoholic fatty liver disease in high-fat diet (HFD)-fed mice. METHODS Male C57BL/6 mice received either normal-fat diet or HFD for 10 weeks along with wild ginseng CMCs (75, 150 and 300 mg/kg) or vehicle (0.5% carboxyl methyl cellulose) by oral administration o...

Here we present the draft genome sequence of Janthinobacterium sp. strain CG3, a psychrotolerant non-violacein-producing bacterium that was isolated from the Cotton Glacier supraglacial stream. The genome sequence of this organism will provide insight as to the mechanisms necessary for bacteria to survive in UV-stressed icy environments.

Reasoning about the evolution of our species' capacity for cumulative cultural learning has led culture–gene coevolutionary (CGC) theorists to predict that humans should possess several learning biases which robustly enhance the fitness of cultural learners. Meanwhile, developmental psychologists have begun using experimental procedures to probe the learning biases that young children actually ...

UNLABELLED The cucumber anthracnose fungus Colletotrichum orbiculare forms specialized cells called appressoria for host penetration. We identified a gene, FAM1, encoding a novel peroxin protein that is essential for peroxisome biogenesis and that associates with Woronin bodies (WBs), dense-core vesicles found only in filamentous ascomycete fungi which function to maintain cellular integrity. T...

We previously found that peroxisomal biogenesis factor 11a (Pex11a) deficiency is associated with a reduction in peroxisome abundance and impaired fatty acid metabolism in hepatocytes, and results in steatosis. In the present study, we investigated whether butyrate induces Pex11a expression and peroxisome proliferation, and studied its effect on lipid metabolism. C57BL/6 mice fed standard chow ...

Zellweger syndrome and related disorders represent a group of lethal, genetically heterogeneous diseases. These peroxisome biogenesis disorders (PBDs) are characterized by defective peroxisomal matrix protein import and comprise at least 10 complementation groups. The genes defective in seven of these groups and more than 90% of PBD patients are now known. Here we examine the distribution of pe...

During the past 10 years, several Pex genes have been knocked out in the mouse with the purpose to generate models to study the pathogenesis of peroxisome biogenesis disorders and/or to investigate the physiological importance of the Pex proteins. More recently, mice with selective inactivation of a Pex gene in particular cell types were created. The metabolic abnormalities in peroxisome defici...

Peroxisomes are small vesicle-like subcellular respiratory organelles present in virtually all eukaryotic cells. Peroxisomes are involved in lipid metabolism, such as β-oxidation of fatty acids, synthesis of sterols and bile acids and also in glyoxylate metabolism and gluconeogenesis [3]. The importance of peroxisomes is underscored by the existence in human of a group of serious metabolic diso...

Abstract Background and Aims The expression role of methyltransferase SET MYND domain-containing protein 5 (SMYD5) in inflammatory bowel diseases (IBD) is completely unknown. Here, we investigated the underlying mechanism epithelial SMYD5 IBD pathogenesis progression. Methods subcellular localization peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) were examined by Weste...