The comparative in vitro skin permeability of diclofenac sodium through excised mouse skin from different common pharmaceutical vehicles like castor oil, olive oil, arachis oil, liquid paraffin, white soft paraffin melt, 3% sodium carboxymethyl cellulose (CMC) aqueous gel and isopropyl myristate (IPM), excluding other excipients was evaluated. Significantly (p < 0.05) higher flux of diclofenac ...

SINCE THE FIRST TRANSDERMAL patch was approved by the US Food and Drug Administration in 1979 to treat motion sickness, patches have become a useful means of delivering drugs for a number of purposes. Still, the barrier properties of the skin mean that currently only modest doses of small, lipophilic drugs can be effectively delivered through the skin. But new research reported by scientists at...

In the present study a new alcohol derivative of tetrahydrogeraniol (THG), an acyclic monoterpene, has been prepared by using Grignard reagent and methyl cyclopropyl ketone. Penetration enhancing effects of THG and the synthesized derivative 5,9-dimethyl-2-cyclopropyl-2-decanol (DICNOL) on the transdermal penetration of 5-fluorouracil (5-FU) and tramadol hydrochloride (tramadol HCl) across the ...

The transdermal application of drugs has attracted increasing interest over the last decade or so, due to the advantages it offers, compared to other delivery methods. The development of an efficient means of transdermal delivery can increase drug concentrations, while reducing their systemic distribution, thereby avoiding certain limitations of oral administration. The efficient barrier functi...

The nail unit is the largest cutaneous musculo-skeletal appendage. management of disorders an onerous task owing to disease manifestations and anatomical structure plate. topical treatment infections/disorders has been a centerpiece research in past few decades as it offers much safer focused alternative conventional oral therapy. However, transungual delivery had its challenges. This necessita...

Transdermal systems are non-invasive, convenient, and inexpensive and can be self-administered. They can provide sustained plasma concentration profile for long periods of time. The systems can greatly improve patient compliance through avoidance of first-past metabolism, improved bioavailability, reduction of systemic side effects and dosing schedule. In the past three decades, transdermal dru...

Simple, safe and effective permeability enhancers are crucial for successful non-invasive drug delivery methods. We seek local permeability augmentation mechanisms for integration into passive or active architectures in order to enable novel therapeutic delivery routes of the target drug while minimizing drug formulation challenges. This study explores the efficacy of hydrogen peroxide (HP) as ...

Purpose: To to develop and evaluate matrix-type ondansetron hydrochloride (OS) transdermal patch for the treatment of chemotherapy-induced nausea and vomiting. Methods: Transdermal patches were prepared by solvent casting method using ethyl cellulose and polyvinyl pyrrolidone as matrix materials, and dibutyl phthalate and dibutyl sebacate as plasticizers. The formulations were evaluated for pat...

Melatonin, a pineal gland hormone can play an important role on circadian rhythms and worked as an internal sleep facilitator in human. Recently, melatonin was used as a drug for treatment of insomnia. The transdermal drug delivery is a good alternative for melatonin delivery because of its variable oral absorption, short half-life, highly first pass metabolism, and a favorable partition coeffi...