نتایج جستجو برای: peritoneal macrophage
تعداد نتایج: 85969 فیلتر نتایج به سال:
Peritoneal exudate cells from nu/nu mice stimulated with proteose peptone broth, but in general not from unstimulated mice, permitted cultures of spleen cells from congenitally athymic (nu/nu) mice to respond to the thymus-dependent antigen fowl gamma globulin (FgammaG). Supernatants of cultures of peritoneal cells were also effective, the activity being sensitive to trypsin. Since nu/nu mice w...
The aim of this study was to evaluate macrophages repolarization from pro-inflammatory M1 to anti-inflammatory M2 phenotype upon transfection with microRNA-223 (miR-223) duplexes and miR-223 expressing plasmid DNA encapsulated in CD44-targeting hyaluronic acid-poly(ethyleneimine) (HA-PEI) nanoparticles (NPs). The HA-PEI/miR-223 NPs with spherical shape and an average diameter of 200 nm were eff...
one of the mechanisms involved in the regulation of the immune system by steroid hormones could be the monocytic-macrophage system. in this study the effect of the male hormone 5a-dht on cytokine release by peritoneal macrophages (mφ) of male and female nzb/balbc mice was investigated. macrophages from male mice activated with lps produced a greater amount of il-1β (21.8%) (p<0.05) and il-6 (19...
Inflammation and macrophage foam cells are characteristic features of atherosclerotic lesions, but the mechanisms linking cholesterol accumulation to inflammation and LXR-dependent response pathways are poorly understood. To investigate this relationship, we utilized lipidomic and transcriptomic methods to evaluate the effect of diet and LDL receptor genotype on macrophage foam cell formation w...
Hamsters immunized with either noninfectious hamster type-C virus (D9) or irradiated D9 tumor cells were tested for cell-mediated immune reactivity by the macrophage migration inhibition assay. The migration of peritoneal exudate cells from immunized hamsters was significantly inhibited by either D9 virus or D9 tumor extract, but not by extract of an unrelated CELO virus-induced tumor. The viru...
Animals systemically infected with various intracellular parasites can show an increased ability to resist subsequent challenge with the same, or certain other, microorganisms . This resistant state is associated with a striking enhancement in the antimicrobial capacity of the fixed macrophages in the liver and spleen, as well as a family of physiologic and morphologic changes in the peritoneal...
Hypoxia-inducible factor (HIF) 1α is a metabolic regulator that plays an important role in immunologic responses. Previous studies have demonstrated that HIF1α participates in the M1 polarization of macrophages. To clarify the mechanism of HIF1α-induced polarization of M1 macrophage, myeloid-specific HIF1α overexpression (Lysm HIF1α lsl) mice were employed and the bone marrow-derived and perito...
The expression of various receptors and other surface determinants on resident, glycogen-and Corynebacterium parvum- elicited mouse peritoneal macrophages has been described. Macrophage Fc (IgG2b) receptors and I-A antigens were slightly increased after stimulation and a more marked increase was shown after activation with C. parvum. Complement receptor expression was enhanced after stimulation...
BACKGROUND The group-specific component protein-derived macrophage-activating factor (GcMAF) has various biological activities, such as macrophage activation and antitumor activity. Clinical trials of GcMAF have been carried out for metastatic breast cancer, prostate cancer, and metastatic colorectal cancer. In this study, despite the complicated purification process of GcMAF, we used enzymatic...
Mouse peri toneal macrophages given a phagocytic stimulus release large amounts o f cyclooxygenase and lipoxygenase metabolites o f arachidonic acid (20:4) (1,2). After macrophage activation th rough intraperi toneal administration of inf lammatory agents, stimulated 20:4 metabolism by peritoneal macrophages is quantitatively and qualitatively al tered (3, 4). T o determine whether downregulat ...
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