Thyroid gland explant cultures from prometamorphic Xenopus laevis tadpoles were evaluated for their utility in assessing chemicals for thyroid hormone (TH) synthesis disruption. The response of cultured thyroid glands to bovine thyroid stimulating hormone (bTSH) and the TH synthesis inhibitors methimazole, 6-propylthiouracil, and perchlorate was determined. Thyroid glands continuously exposed f...

To understand the mechanisms for endocytic sorting of lipids, we investigated the trafficking of three lipid-mimetic dialkylindocarbocyanine (DiI) derivatives, DiIC16(3) (1,1'-dihexadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate), DiIC12(3) (1,1'- didodecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate), and FAST DiI (1,1'-dilinoleyl-3,3,3', 3'-tetramethylindocarbocyanine perchlora...

This article is a brief review and summary of the estimated incremental risks (increases in hazard quotient or decreases in thyroid uptake of iodine) to pregnant women (and hence their fetuses) associated with perchlorate exposure in community water supplies (CWSs) . The analysis draws on the recent health effects review published in 2005 by the National Research Council (NRC) . We focus on the...

This study was undertaken to determine if increasing maternal iodine intake through single dose tablets will decrease breast milk concentrations of the iodine-uptake inhibitor, perchlorate, through competitive inhibition. We also sought to determine if the timing of supplementation influences the fraction of iodine excreted in milk versus urine and to compare the effectiveness of iodized salt a...

erchlorate is a highly soluble salt anion that can negatively affect the ability of the human thyroid to adequately uptake iodide (Greer et al, 2002; Wolf, 1998). Since early 1997, perchlorate analytical techniques have significantly improved. As a result, drinking water testing performed throughout the United States has uncovered perchlorate contamination in several regions of the country at l...

The asymmetric unit of the title compound, [Ru(C12H8N2)3](ClO4)2, contains one octahedrally coordinated Ru(II) cation of the ruthenium-phenanthroline complex and three differently occupied perchlorate anions: two, denoted A and B, are located on the twofold axis while another, denoted C, is positioned in the proximity of the twofold screw axis. Perchlorate anions B and C are severely disordered...

The title complex, [Cd(C(6)H(17)N(3))(2)](ClO(4))(NO(3)), was synthesized by the reaction of Cd(NO(3))(2)·4H(2)O, bis-(3-amino-prop-yl)-amine and sodium perchlorate in methanol. The asymmetric unit of the title complex consists of one Cd(2+) cation, two tridentate bis-(3-amino-prop-yl)amine ligands, one nitrate anion and one perchlorate anion. The Cd(2+) cation is coordinated by six N atoms of ...

Achira (Canna indica L.) has not yet been tested for its potential in removing perchlorate (ClO4−) from wastewater. In this study, constructed wetlands with and without achira were used to investigate the removal efficiency mechanism of perchlorate. The results showed that more ClO4− was removed by relative those without. Perchlorate decreased time, whereas stably removed. terms content, tissue...