The use of nanomaterials for enhancement the antibacterial activity different compounds is a new approach contributing to efforts overcoming emerging antibiotics resistance. This study explores combined nanodiamonds and snail peptides against Brevibacillus laterosporus BT271. Two peptide/protein fractions from Cornu aspersum mucus were used – with molecular weight (MW) below 10 kDa MW above 30 ...

Mass spectrometry combined with the use of isotope-labeled standards is one favored methods for quantitative measurement beta-amyloid concentrations in biological media. This article devoted to prevention typical systematic errors such measurements arising from neglect possibility transformation into denatured form, which gives mass spectra signals three times more intensity than native form. T...

Peptides have fantastic functions like prions pathogens that cause transmissible diseases devoid of nucleic acid. Furthermore, because their high specificity, peptides can be used in antitumor therapy to target specific targets. In this work we describe the vitro action against B16F10 cells a peptide named W12K obtained from immunoglobulin gene. As result, showed growing experimental trials suc...

Discovering dominant epitopes for T cells, particularly CD4+ in human immune-mediated diseases remains a significant challenge. Here, we used bronchoalveolar lavage (BAL) cells from HLA-DP2–expressing patients with chronic beryllium disease (CBD), debilitating granulomatous lung disorder characterized by accumulations of beryllium-specific (Be-specific) the lung. We discovered lung-resident tha...

DOI: 10.1002/jssc.202100066 The cover picture shows a schematic diagram of liquid chromatography with tandem mass spectrometry method for analyzing microsomal and soluble epoxide hydrolase in rat heart, kidney, liver S9 samples. Protein quantification was realized through targeted proteomics the determination trypsin-specific surrogate peptides after digestion. A multiple reaction monitoring po...

Crystallographic data analyses indicate that three types of prolinium cations, along with two types of hydrogen bonding, produce and stabilize the helical structure of triprolinium 12-phosphomolybdate. There are similarities between this organic-inorganic compound and peptides/proteins. The stronger “conventional” hydrogen bonds and the less common C-H…O attractions play critical roles in gener...

Crystallographic data analyses indicate that  three types of prolinium cations, along with two types of hydrogen  bonding,  produce and stabilize the helical structure of  triprolinium 12-phosphomolybdate. There are similarities between this organic-inorganic compound and peptides/proteins. The stronger “conventional” hydrogen bonds and the less common C-H…O attractions play critical roles in g...

Objective: Cancer has risen as the main cause of diseases with the highest rate of mortality in the world. Drugs used in cancer, usually demonstrate side effects on normal tissues. On the other hand, anticancer small peptides, effective on target tissues, should be safe on healthy organs, as being naturally originated compounds. In addition, they may have good pharmacokinetic properties. carnos...

Key words rhodium catalysis - unnatural peptides three-component reaction carboamination dioxazolones arylboronic acids acrylamides