The cardiac sarcolemmal Na 1 -Ca 2 1 exchanger is modulated by intrinsic regulatory mechanisms. A large intracellular loop of the exchanger participates in the regulatory responses. We have proposed (Li, Z., D.A. Nicoll, A. Collins, D.W. Hilgemann, A.G. Filoteo, J.T. Penniston, J.N. Weiss, J.M. Tomich, and K.D. Philipson. 1991. J. Biol. Chem. 266:1014–1020) that a segment of the large intracell...

In this paper, a fully automatic scheme for hiding digital watermarks into face regions is proposed. To achieve this goal, an adaptive two-dimensional Gaussian model of skin color distribution is initially used in order to detect face regions within the initial image. Next each face region is decomposed into three levels with ten subbands, using the Discrete Wavelet Transform (DWT) and three pa...

We describe an iterative procedure for optimizing policies, with guaranteed monotonic improvement. By making several approximations to the theoretically-justified procedure, we develop a practical algorithm, called Trust Region Policy Optimization (TRPO). This algorithm is similar to natural policy gradient methods and is effective for optimizing large nonlinear policies such as neural networks...

Koji Nomura ', Wataru Saito Kimiyo Ono2, Hiromitsu Moriyama3, Seiko Takahashi4, Inoue4 and Kiyoshi MasudaS i institute ofAgriculture and R)restt),, University of Tlsukubq 71vukuba, Ibaraki, 305 Jopan 2 institute ofBiologicat Science, Uhiversity of 7lsukuba, 7lsukuba, Ibaraki, 305 Japan 3 Ricuity ofAgricutture, Tbkyo Uhiversity ofAgrieutture and Tlechnology, Fuchu, Tbkyo, 183 Japan ` Division of...

This paper describes a memory management discipline for programs that perform dynamic memory allocation and de-allocation. At runtime, all values are put into regions. The store consists of a stack of regions. All points of region allocation and de-allocation are inferred automatically, using a type and effect based program analysis. The scheme does not assume the presence of a garbage collecto...

The Hebbian hypothesis of activity-dependent synaptic plasticity has gained much support from experimental studies of long-term potentiation and depression. Such studies have also uncovered complex patterns of competition among the synapses. Such e ects may be due to the neuron redistributing its limited synaptic resources as synaptic strengths change. In computational models this strategy is c...

The Region Connection Calculus (RCC) is one of the most widely referenced system of high-level (qualitative) spatial reasoning. RCC assumes a continuous representation of space. This contrasts sharply with the fact that spatial information obtained from physical recording devices is nowadays invariably digital in form and therefore implicitly uses a discrete representation of space. Recently, G...

Recently, correlation filters have demonstrated the excellent performance in visual tracking. However, the base training sample region is larger than the object region, including the Interference Region (IR). The IRs in training samples from cyclic shifts of the base training sample severely degrade the quality of a tracking model. In this paper, we propose the novel Region-filtering Correlatio...

A regional optimization of automatically generated machining toolpath for computer based freeform mechanical models is considered in the framework of multi-axis (three to ve) machining operations. Consider a trichotomy of an arbitrary freeform shaped surface into convex, concave and saddle-like regions. Saddle-like and concave regions can be milled using a ball end tool, in a 3or a 5-axis mode....