The autonomic nervous system plays an important role in rat anaphylactic hypotension. It is well known that sympathetic nerve activity and cardiovascular function are affected by anesthetics. However, the effects of different types of anesthesia on the efferent renal sympathetic nerve activity (RSNA) during anaphylactic hypotension remain unknown. Therefore, we determined the renal sympathetic ...

UNLABELLED It is unclear whether general anesthetics induce enhancement of neural inhibition and/or attenuation of neural excitation. We studied the effects of pentobarbital (5 x 10(-4) mol/L), propofol (5 x 10(-4) mol/L), ketamine (10(-3) mol/L), halothane (1.5 vol%), and isoflurane (2.0 vol%) on both excitatory and inhibitory synaptic transmission in rat hippocampal slices. Excitatory or inhi...

The synthesis of radioactive urea (Cr4) of high specific activity* permits one to trace the metabolism of urea and many of its readily synthesized derivatives, i.e. the barbiturates. The universal use of the barbiturates in clinical medicine makes an investigation of their metabolism in the animal of interest. Pentobarbital sodium (nembutal) (tagged with C4, specific activity 8400 counts per se...

The functional consequences of the differences in lipid composition and structure between the two leaflets ofthe plasma membrane were investigated. Fluorescence of 1,6-diphenylhexa1,3,5-triene (DPH), quenching, and differential polarized phase fluorimetry demonstrated selective fluidization by local anaesthetics of individual leaflets in isolated LM-cell plasma membranes. As measured by decreas...

We studied the pharmacology of the GABA receptors on bipolar cell terminals in the retinal slice preparation. Whole-cell patch-clamp recordings were made from the somas of bipolar cells and GABA was puffed near their terminals, after synaptic transmission was blocked. GABA puffs evoked a large chloride current that was reduced by picrotoxin, but in many cells this current was insensitive to blo...