It has been shown (Odegaard, 1962) by sensitivity testing in vitro that the effect of ampicillin on most gonococcal strains is somewhat weaker than that of penicillin G, but the effect on strains less sensitive is better with ampicillin than with penicillin G. Reyn and Bentzon (1968), in support of this, found that the 50 per cent. inhibitory concentrations for the naturally-occurring more sens...

Eagle (1947a) has shown that p-hydroxybenzyl penicillin (X) was more effective than benzyl penicillin (G) in curing mice infected with Streptococcus pyogenes and Streptococcus pneumoniae. Hewitt and Pittman (1946) have obtained similar results in animals infected with Hemophilus influenzae. It was further shown that penicillin X remains in the blood of human subjects longer than penicillins G o...

Benzylpenicillin potassium (penicillin G) is a narrow-spectrum penicillin (active against Grampositive aerobes, facultative aerobes and obligate anaerobes), often used in rabbits for treatment of pasteurellosis, odontogenic abscesses and treponematosis. However, several dosages and treatment regimes have been advocated; three times daily, once a day, or once every two or seven days (Welch et al...

Two patients developed neurosyphilis after treatment of latent syphilis with intramuscular benzathine penicillin. The cases confirm recent investigations that show that neither benzathine penicillin nor procaine penicillin in the standard doses results in treponemicidal concentrations of penicillin in cerebrospinal fluid. Neurosyphilis can be treated effectively by intravenous benzylpenicillin ...

The deacetoxycephalosporin C synthase from Streptomyces clavuligerus was directly modified for enhancement of penicillin G expansion into phenylacetyl-7-aminodeacetoxycephalosporanic acid, an important intermediate in the industrial manufacture of cephalosporin antibiotics. Nine new mutants, mutants M73T, T91A, A106T, C155Y, Y184H, M188V, M188I, H244Q, and L277Q with 1.4- to 5.7-fold increases ...

Penicillinase production and minimum inhibitory concentrations (MICs) of penicillin G, amoxycillin, doxycycline, and spectinomycin were studied for 155 gonococcal strains isolated in Fukuoka, Japan, between April and December 1981. Of 155 isolates, 25 (16.1%) strains were identified as penicillinase-producing Neisseria gonorrhoeae (PPNG) by a rapid iodometric test. The antibiotic sensitivity of...