Background: Pemphigus is an autoimmune bullous disease and it is unclear what triggers and deteriorates it. The current study aimed to evaluate whether increasing the IgG antibody titer represents a good indicator of the pemphigus recurrence. Objectives: The current study aimed to evaluate whether increasing IgG titer is an indicator of the expected recurrence. Patients and Methods: The current...

Pemphigus vegetans is a clinical variant of pemphigus vulgaris, accounting for 1-2% of all very rare pemphigus cases in children. The involvement of the oral mucosa in this disease is usually accompanied by severe pain that aggravates the patient's malnourished condition. Conversely, malnutrition may also reduce vulnerability towards autoimmune diseases. Although pemphigus vegetans has never be...

Pemphigus consists of a group of chronic blistering skin diseases mediated by autoantibodies (autoAbs). The dogma that pemphigus is caused by keratinocyte dissociation (acantholysis) as a distinctive and direct consequence of the presence of autoAb targeting two main proteins of the desmosome-desmoglein (DSG) 1 and/or DSG3-has been put to the test. Several outside-in signaling events elicited b...

Dermatol 2006;142:570–6. 21 Beissert S, Werfel T, Frieling U et al. A comparison of oral methylprednisolone plus azathioprine or mycophenolate mofetil for the treatment of pemphigus. Arch Dermatol 2006;142:1447–54. 22 Ahmed AR, Spigelman Z, Cavacini LA, Posner MR. Treatment of pemphigus vulgaris with rituximab and intravenous immune globulin. N Engl J Med 2006;355:1772–9. 23 Joly P, Mouquet H, ...

INTRODUCTION Paraneoplastic pemphigus is an autoimmune disease associated with an underlying tumor. Several cases have been reported as unusual pemphigus vulgaris, erythema multiforme, or paraneoplastic bullous disease, but the incidence of the condition is unknown. Response to treatment is generally poor, with significant morbidity and mortality. This condition is clinically characterized by s...

Dsg: desmoglein H&E: hematoxylin-eosin IL: interleukin PH: pemphigus herpetiformis INTRODUCTION Pemphigus herpetiformis (PH) is a rare variant of pemphigus and accounts for approximately 7% of cases. PH combines the clinical features of dermatitis herpetiformis with the histologic features of pemphigus. Clinically, the plaques are herpetiform or even annular. PH follows a more benign course wit...

The Pemphigus vulgaris (PV) is a group of highly lethal autoimmune disease characterized by mucocutaneous erosions or blisters. Pemphigus vulgaris can be present in different forms like oral and topical. So, it is challenging to manage and treat. Mortality rate due to Pemphigus vulgaris can be decreased by using systemic corticosteroids, but the present treatment options are limited due to the ...

To the Editor: Pemphigus foliaceus (PF) is a chronic autoimmune blistering disease caused by pathogenic serum autoantibodies against desmoglein 1. Initial treatments for PF include systemic corticosteroids, immunosuppressants, and dapsone.1 Rituximab, chimeric monoclonal antibody specific to CD20 molecule on B cells, was shown be effective severe refractory cases of pemphigus in meta-analysis.2...

Inducible regulatory T cell (iTreg) is highly expected to exert antigen-specific immunosuppression in autoimmune diseases. A major obstacle clinical application the functional instability of iTreg vivo that associated with gene methylation immunoregulatory molecules. To overcome this problem, here we generated stabilized (siTreg) by optimizing culture conditions CDK8/19 inhibitor and retinoid a...