Autoimmune blistering diseases (pemphigus vulgaris, pemphigus foliaceus, bullous pemphigoid, dermatitis herpetiformis) and certain genodermatoses with acantholysis (Darier-disease, Hailey-Hailey disease) have different aetiological factors, but all result in bulla formation and/or in acantholysis. Cadherins are Ca++-dependent cell-cell adhesion molecules which play an important role in the cell...


 We did not find any evidence regarding the clinical effectiveness and safety of alternative treatments to IV immunoglobulin (IVIg) compared IVIg or placebo for bullous pemphigoid (BP) pemphigus vulgaris (PV) foliaceus (PF) that met our inclusion criteria this review.
 identified 6 consensus guidelines presenting treatment algorithms BP (3 guidelines) PV PF guidelines). All recommend...

p38 mitogen activated protein kinase (p38 MAPK) signaling plays a major role in the modulation of immune-mediated inflammatory responses and therefore has been linked with several autoimmune diseases. The extent of the involvement of p38 MAPK in the pathogenesis of autoimmune blistering diseases has started to emerge, but whether it pays a critical role is a matter of debate. The activity of p3...

Background Pemphigus is a severe bullous autoimmune skin disease. foliaceus (PF) characterized by antidesmoglein (Dsg) 1 IgG causing epidermal blistering; mucosal pemphigus vulgaris (mPV) anti-Dsg3 inducing erosions in the mucosa; and mucocutaneous (PV) affecting both, with autoantibodies targeting Dsg1 Dsg3. Objectives To characterize Ca2+ flux pathway delineate its importance pathogenesis cli...

BACKGROUND Pemphigus is an acquired autoimmune intraepidermal blistering disease that is divided into 2 major subtypes: pemphigus vulgaris (PV) and pemphigus foliaceus (PF). Patients with pemphigus have circulating anti-desmoglein (Dsg)1 and/or anti-Dsg3 IgG autoantibodies. Recently, a novel commercial enzyme-linked immunosorbent assay (ELISA) against Dsg1 and Dsg3 has been established and foun...