OBJECTIVE Homeobox genes are transcriptional regulators that orchestrate embryonic development. The HOXA13 gene is responsible for the development of the vagina and regulates extracellular matrix constituents. We hypothesized that vaginal expression of HOXA13 may be decreased in women with pelvic organ prolapse (POP) and sought to determine if hypoestrogenism affects its expression. METHODS B...

Background: Pelvic organ prolapse is a descent of the pelvic organs into vagina, frequently associated with local symptoms. floor support essential to maintain normal anatomy. Recent studies genital suggests that it more important improve patient satisfaction and reduce complication than achieve anatomical success. The purpose audit management in this retrospective study know understand decisio...

Pelvic organ prolapse (POP) is a disabling disorder in women characterized by a loss of pelvic floor support, leading to the herniation of the uterus into or through the vagina. POP is a complex problem that likely involves multiple mechanisms with limited therapies available, and is associated with defects in connective tissue including elastic fibers. This study was designed to investigate th...

Objectives: To compare the follow-up results of a sacrospinous ligament fixation (SSLF) technique for laparoscopic bilateral vagina to iliopectineal via PVDF-mesh (laparoscopic pectopexy technique, LP) in terms cure rate and postoperative complications rate. Material methods: This prospective study included 160 patients diagnosed with pelvic organ prolapse stage II–IV according POP-Q system. Ei...

BACKGROUND The last decade has seen significant progress in understanding of the pathophysiology, anatomy and management modalities of pelvic organ prolapse. A review of the way we manage this entity in a low resource setting has become necessary. AIM The aim of the study is to determine the incidence, risk factors and management modalities of pelvic organ prolapse. MATERIALS AND METHODS A ...

BACKGROUND Pelvic organ prolapse is a common health problem, affecting up to 40% of parous women over 50 years old, with significant negative influence on quality of life. Vaginal hysterectomy is currently the leading treatment method for patients with symptomatic uterine prolapse. Several studies have shown that sacrospinous fixation in case of uterine prolapse is a safe and effective alternat...

OBJECTIVE The purpose of this study was to measure the rate of reoperation for surgically treated pelvic organ prolapse. STUDY DESIGN An 11-year retrospective audit was conducted of women who had undergone surgery for pelvic organ prolapse between 1995 and 2005 in a large teaching hospital in the UK. Main outcome measure Variables examined included the type of primary procedure for pelvic org...

OBJECTIVE At present little information is available to help define whether a certain degree of pelvic organ prolapse is clinically relevant. We performed a retrospective study to define cut-offs for significant pelvic organ descent on the basis of prolapse symptoms. METHODS At a tertiary urogynecological center, 735 women with symptoms of lower urinary tract dysfunction and prolapse were see...

BACKGROUND Female pelvic organ prolapse is common and generally thought to worsen over time. This assumption has recently become less plausible, as the author and others have been able to show that mild to moderate pelvic organ descent is common in young, nulligravid women. AIMS To investigate the relationship between age and pelvic organ prolapse. METHODS The records of 1110 women seen for...