This study describes the synthesis of two new families of dendrimers based on the esterification of N-alkylated 3-amine-1-propanol with two different cores, adipic acid (1st and 2nd generations) and ethylenediamine (generation 1.5), both with carboxylic acid end groups, offering a wide variety of further modifications at the periphery. According to the cytotoxic evaluation of the dendrimers and...

Dendrimers are large polymeric structures with nanosize dimensions (1-10 nm) and unique physicochemical properties. The major advantage of dendrimers compared with linear polymers is their spherical-shaped structure. During synthesis, the size and shape of the dendrimer can be customized and controlled, so the finished macromolecule will have a specific "architecture" and terminal groups. These...

A phenomenological coupled exciton model is proposed in order to characterize optical excitations in extended dendrimers. An onsite exciton state is assigned at each phenyl rings and a nearest neighbor hopping integral which obeys the Gaussian distribution is considered between the exciton states. The decreasing optical excitation energy with respect to the dendrimer size indicates the presence...

large unilamellar liposomes and multilamellar vesicles consisting of dmpc interacted with cationic phosphorus-containing dendrimers cpds g3 and g4. dsc and ζ -potential measurements have shown that liposomal-dendrimeric molecular recognition occurs due to the interaction between the complementary surface groups. calorimetric studies indicate that the enthalpy of the transition of the lipids tha...

The multivalent character of dendrimers has positioned these well-defined, highly branched macromolecules at the forefront in the development of new contrast agents for biomedical magnetic resonance imaging (MRI). By modifying the periphery of the dendrimer with gadolinium(III) chelates, the relaxivity of the resulting MRI contrast agent is increased considerably, compared to low molecular weig...

Investigations have been carried out to probe the interactions between double-stranded DNA and amineterminated, ethylenediamine core polyamidoamine starburst dendrimers generation 2 (G2), generation 4 (G4), and generation 7 (G7). Ethidium bromide is used as a fluorescent probe for this study. Under our experimental conditions, the results show that there is mainly one binding mode between ethid...

The improvement of aqueous solubility of methyl (5-[propylthio]-1H-benzimidazol-2-yl) carbamate, albendazole (ABZ) using polyamidoamine (PAMAM) dendrimers as solubility enhancers was investigated. Full generation PAMAM dendrimers with amine terminal groups, (G3), with hydroxyl terminal groups (G3OH) and half generation PAMAM dendrimers with carboxylate terminal groups (G2.5 and G3.5), were chos...

Dendrimers are new artificial macromolecules which have the structure like a tree. They are hyperbranched and monodisperse three-dimensional molecules with defined molecular weights, large numbers of functional groups on the surface and well-established host-guest entrapment properties. Recently, dendrimers have successfully proved themselves as promising nanocarriers for drug delivery because ...

Dendrimers are macromolecular, nanoscale objects that are widely recognized as precise, mathematically defined, covalent core-shell assemblies. As such, they are composed of quantized numbers of atoms, monomers, and terminal functional groups relative to the respective shell levels (generations) surrounding their cores. Dendrimers have been referred to as molecular-level analogs of atoms. This ...

We perform monomer-resolved computer simulations of fourth-generation charged dendrimers at various conditions of charging (full, terminal and neutral) and for different values of the spacer length P connecting the branching nodes, fromP1⁄4 1 toP1⁄4 6.We examine the sizes, overlaps and effective forces between the centers ofmass of the dendrimers with andwithout addedmonovalent and divalent sal...