Targeted delivery and controlled release of inactive platinum (Pt) prodrugs may offer a new approach to improve the efficacy and tolerability of the Pt family of drugs, which are used to treat 50% of all cancers today. Using prostate cancer (PCa) as a model disease, we previously described the engineering of aptamer (Apt)-targeted poly(D,L-lactic-co-glycolic acid)-b-poly(ethylene glycol) (PLGA-...

Myrrh has long been used for its circulatory, disinfectant, analgesic, antirheumatic, antidiabetic, and schistosomicidal properties. Myrrh essential oil (MEO) was extracted from the oleo-gum resin of Commiphora molmol and formulated into emulsions and suppositories to mask/avoid its bitter taste. Three oil-in-water emulsions (E1-E3) were formulated and taste was evaluated by 10 volunteers. Part...

In this work, a nanofiber mat based on PHB/PEG with various PEG contents was obtained by electrospinning process. The thermal and mechanical properties of the were investigated. addition, mats characterized Fourier transforms infrared spectroscopy (FTIR), differential scanning calorimetry, thermogravimetric analysis, X-ray diffraction, water contact angle measurement. It shown that, increasing ...

NADH-localized fluorometry was used as a noninvasive technique to monitor changes in the energy state of intact tissue (muscle and connective tissue), without anesthesia, as a function of blood plasma O(2)-carrying capacity in the hamster window chamber model. Acute moderate isovolemic hemodilution was induced by two isovolemic hemodilution steps: in the first step, 6% 70-kDa dextran (Dex70) wa...

Ph. Vanderbemden,1 Z. Hong,2 T. A. Coombs,2 S. Denis,3 M. Ausloos,4 J. Schwartz,5 I. B. Rutel,5 N. Hari Babu,6 D. A. Cardwell,6 and A. M. Campbell6 1SUPRATECS and Department of Electrical Engineering and Computer Science B28, Sart-Tilman, B-4000 Liège, Belgium 2Centre for Advanced Photonics and Electronics, Engineering Department, University of Cambridge, 9 JJ Thomson Avenue, Cambridge CB3 0FA,...

Several treatments are currently available for relapsing-remitting multiple sclerosis. Among them, interferon (IFN) beta remains a valid treatment approach because of its good benefit/risk profile. Due to the need for frequent administration (weekly, at a minimum), the use of IFN beta is limited by uncomfortable side effects that could reduce adherence to and persistence with the treatment. The...

Blacks have significantly higher rates of hypertension than whites, and lower circulating levels of 25-hydroxyvitamin D. There are few data about the effect of vitamin D3 (cholecalciferol) supplementation on blood pressure in blacks. During 2 winters from 2008 to 2010, 283 blacks (median age, 51 years) were randomized into a 4-arm, double-blind trial for 3 months of placebo, 1000, 2000, or 4000...

BACKGROUND Results of meta-analyses of randomized trials comparing PEG and NaP are inconsistent and have not included trials comparing either or both preps to less traditional ones. AIM To perform a meta-analysis by treatment arm. METHODS Using MEDLINE and EMBASE, we identified English-language trials published from 1990 to 2008 that included PEG and/or NaP, and aggregated them by treatment...