19 Fluoroquinolones are among the drugs of choice for treatment of salmonella infections. However, 20 fluroquinolone resistance is increasing in salmonella due to chromosomal mutations in the quinolone 21 resistance-determining region (QRDR) of the topoisomerase genes gyrA, gyrB, parC and parE and/or plasmid22 mediated quinolone resistance (PMQR) mechanisms including qnr variants, aac(6’)-Ib-cr...

STUDY OBJECTIVE A dose-ranging study was conducted to evaluate the efficacy and safety of a new long-acting, selective beta 2-adrenoceptor agonist, salmeterol. DESIGN Adolescents and adults (N = 160) with mild-to-moderate asthma received salmeterol (10.5, 21, 42, or 84 micrograms) or placebo by metered-dose inhaler twice daily for 1 week. Twelve-hour serial spirometry measurements were perfor...

to nalidixic acid. Chemically, PFM, is 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-peperazinyl)-4-oxo-3-quinolinecarboxylic acid, methane sulfonate dihydrate (Fig. 1). It is an antibacterial drug, which is highly effective against both Gram-negative and Gram-positive pathogens that are resistant to other antibacterials (1). The therapeutic importance of PFM has necessitated the development of an...

Smoothie-type beverages are usually preserved by mild pasteurisation (MP) but combining moderate heat (H) and pulsed electric fields (PEF) could represent an alternative technique achieving similar, or better, microbiological safety and shelf life, and possibly lowering the thermal impact on physical and sensory product properties. Following H (55 C after 60 s) and PEF (34 kV/cm, 60 ms) the mic...

Nineteen patients with chronic airflow obstruction measured their morning and evening peak expiratory flow (PEF) daily for 28 days. A placebo was taken for the first week and prednisolone 20 mg twice daily was taken for the last three weeks. The mean PEF in 13 patients who responded to prednisolone reached a maximum after eight days' treatment. The majority of the 19 patients had asthma and wer...