asthma is the most common chronic disease in children. the natural history of asthma is often  characterized by periods  of  remission and  relapse. the  aim of  this study was to determine the remission rate of asthmatic children after entering the second decade of life and remission related factors in a hospital–based cohort. the  study  population  was  asthmatic  children  who  were  diagno...

  Background Endothelial Cell-Specific Molecule-1 (ESM-1) is a 50 kDa soluble proteoglycan that is produced mainly the vascular endothelial cells of the kidney and lung. It is produced by the effects of proangiogenic and pro-inflammatory cytokines, and it indicates activation and dysfunction of the vascular endothelium. We aimed to detect the role of ESM-1 in childre...

1Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany; 2Department of Clinical Immunology, University Hospital Freiburg, Freiburg, Germany; 3Department of Pediatric Hematology, Hacettepe University, Children’s Hospital, Ankara, Turkey; 4Immunology, Asthma and Allergy Research Institute, Medical Sciences/University of Tehran, Tehran, Iran; and 5Department o...

Pediatric asthma has been well researched and actively managed in Southern Africa for many years. From the earliest study of asthma prevalence in 1979 revealing a significant rural – urban asthma gradient to more recent studies suggesting that asthma now abounds in all population and socio-economic groups, Southern Africa has been the subject of a significant number of publications relating to ...

OBJECTIVE To describe the development of a Web-based multihospital pediatric asthma tracking system and present results from the initial 18-month implementation of patient tracking experience. DESIGN The Emergency Department (ED) Allies tracking system is a secure, password-protected data repository. Use-case methodology served as the foundation for technical development, testing, and impleme...

At its introduction in the management of pediatric asthma, montelukast was regarded as a potentially revolutionary drug due to mechanism action and easy clinical applicability. Nevertheless, use daily practice evidence from trials have shown that, rather than radical change approach asthmatic children, more likely represents second-line medication that is useful when inhaled steroids alone fail...

OBJECTIVE To test the reliability and validity of the Asthma Trigger Inventory (ATI) applied to a pediatric population. METHOD Children with asthma (N = 272, 56% male, age 7-17) and their primary caregivers answered together an asthma trigger inventory, ATI (Ritz, Steptoe, Bobb, Harris, & Edwards, 2006) developed for adults. Cronbach's alpha, principal component analysis (PCA), hierarchical r...

Respiratory tract disorder is a very common problem faced by pediatric population, asthma being one of the most common chronic disorders in young children. Many preschool children regularly wheeze, especially during common cold infection and cold seasons. Some children wheeze after a simple exercise or some after the introduction of medication like aspirin or after introduction to allergens. An...