We report synthetic strategies for installing platinum group metals (PGMs: Pd, Rh, Ir, and Pt) on a scorpionate-derived linker (TpmC*) within metal-organic framework (MOF), both by room-temperature postsynthetic metalation direct solvothermal synthesis, with wide range of metal loadings relevant fundamental studies catalysis. In-depth the palladium adduct Pd(II)@Zr-TpmC* density-functional-theo...

The therapy of different advanced-stage malignancies with monoclonal antibodies blocking programmed cell death protein 1 (PD-1)/PD-1 ligand 1 (PD-L1) signaling has had an impressive long-lasting effect in a portion of patients, but in most cases, this therapy was not successful, or a secondary resistance developed. To enhance its efficacy in treated patients, predictive biomarkers are searched ...

Peritoneal dialysis (PD) leads to structural and functional changes in the peritoneal membrane, endpoint of which is fibrosis. fibrosis diagnosed 50% 80% PD patients within 1 2 years treatment initiation, respectively. A key role development played by mesothelial-mesenchymal transformation, a complex biological process transition from mesothelium mesenchyme. This review summarizes current knowl...

Parkinson’s disease (PD) is characterized by the selective loss of dopaminergic neurons of the substantia nigra pars compacta (SNpc). Proteostasis impairment at the level of the endoplasmic reticulum (ER) is emerging as a driving factor of dopaminergic neuron loss in PD. ER stress engages the activation of an adaptive reaction known as the unfolded protein response (UPR) to recover proteostasis...

Complex formation between [Pd(H2O)4](2+) and oxalate (ox = C2O4(2-)) has been studied spectrophoto-metrically in aqueous solution at variable temperature, ionic strength and pH. Thermodynamic parameters at 298.2 K and 1.00 mol dm(-3) HClO4 ionic medium for the complex formation [Pd(H2O)4](2+) + H2ox ⇄ [Pd(H2O)2(ox)] + 2H3O(+) with equilibrium constant K1,H (in mol dm(-3)) are log10K1,H = 3.38 ±...

Parkinson’s disease (PD) affects over 500,000 Americans. Most cases of PD are idiopathic, or occurring without a known cause. Two pathological features of PD, α-synuclein-rich Lewy bodies (LB) and oxidative damage, hint at the cause of the disease. Yet, disparities in recessive forms of PD increase the complexity of the disease mechanism. These recessive forms occur earlier in life and are devo...

Immune-evasion and immune checkpoints are promising new therapeutic targets for several cancer entities. In ovarian cancer, the clinical role of programmed cell death receptor ligand 1 (PD-L1) expression as mechanism to escape immune recognition has not been clarified yet. We analyzed PD-L1 expression of primary ovarian and peritoneal tumor tissues together with several other parameters (whole ...

BACKGROUND Complex visual hallucinations (VHs) occur in several pathologic conditions; however, the neural mechanisms underlying these symptoms remain unclear. Although dopamine may have a role, indirect evidence indicates that serotonin may also contribute to the pathogenesis of complex VHs, probably via involvement of the serotonin 2 receptor. OBJECTIVE To examine for the first time in vivo...

Mitochondria likely play a role in Parkinson's disease (PD) neurodegeneration. We modelled PD by creating cytoplasmic hybrid (cybrid) cell lines in which endogenous mitochondrial DNA (mtDNA) from PD or control subject platelets was expressed within human teratocarcinoma (NT2) cells previously depleted of endogenous mtDNA. Complex I activity was reduced in both PD cybrid lines and in the platele...

Large scale syntheses of uniform metal nanoparticles with hollow porous structure have attracted much attention owning to their high surface area, abundant active sites and relatively efficient catalytic activity. Herein, we report a general method to synthesize hollow porous Pd nanospheres (Pd HPNSs) by templating sacrificial SiO2 nanoparticles with the assistance of polyallylamine hydrochlori...