Centrosomes consist of two centrioles surrounded by an amorphous pericentriolar matrix (PCM), but it is unknown how centrioles and PCM are connected. We show that the centrioles in Drosophila embryos that lack the centrosomal protein Centrosomin (Cnn) can recruit PCM components but cannot maintain a proper attachment to the PCM. As a result, the centrioles "rocket" around in the embryo and ofte...

The centrosome influences the shape, orientation and activity of the microtubule cytoskeleton. The pericentriolar material (PCM), determines this functionality by providing a dynamic platform for nucleating microtubules and acts as a nexus for molecular signaling. Although great strides have been made in understanding PCM activity, its diffraction-limited size and amorphous appearance on electr...

The sensitivity of bacteria to the bactericidal activity of serum depends on the structure and organization of the bacterial outer membrane. Sialic acid has been found in the O-specific region of bacterial lipopolysaccharide (LPS) and it plays an essential role in protecting Gram-negative bacteria against the bactericidal activity of human and animal serum. The susceptibility of Gram-negative b...

A new simple and sensitive ratio-spectra first derivative spectrophotometric method was developed for the simultaneous determination of tapentadol hydrochloride (TPH) and paracetamol (PCM) in binary mixtures. The method depends on the use of the first derivative of the ratio-spectra obtained by dividing the absorption spectrum of binary mixture by a standard spectrum of one of the compounds. TP...

In this article TENCompetence will be presented as a framework for lifelong competence development. More specifically, the relationship between the TENCompetence framework and the IMS Learning Design (LD) specification is explored. LD authoring has proven to be challenging and the toolset currently available is targeting expert users mostly working for institutions of higher educations. Further...

Proteochemometric modeling (PCM) is a computational approach that can be considered an extension of quantitative structure-activity relationship (QSAR) modeling, where a single model incorporates information for a family of targets and all the associated ligands instead of modeling activity versus one target. This is especially useful for situations where bioactivity data exists for similar pro...

The calculation of vertical electronic transition energies of molecular systems in solution with accurate quantum mechanical methods requires the use of approximate and yet reliable models to describe the effect of the solvent on the electronic structure of the solute. The polarizable continuum model (PCM) of solvation represents a computationally efficient way to describe this effect, especial...

Integration of phase-change materials (PCMs) into building fabrics is considered to be one of the potential and effective ways of minimising energy-consumption and CO2-emissions in the building sector. In order to assess the thermal effectiveness of this concept, composite PCM drywall samples (i.e., randomly mixed and laminated PCM drywalls) have been evaluated in a model passive-solar building...

Experiments have been performed on the thermal behavior of a collector–storage wall system using PCM (phase change material). PCM slabs were attached on the gap-side wall surface to increase the heat storage. The test was carried out for a whole day with charging period of 6.5 h and discharging period of 17.5 h, respectively. Wall and air temperatures as well as air velocity in the gap were mea...

This study was conducted to apply a phase change material (PCM) to the inner skin part of a double skin facade to positively utilize natural solar heat so that a double skin facade may not only counteract external environmental changes but also positively introduce external natural solar energy, highlighting the advantages of a double skin facade. However, PCM is currently used by impregnating ...