Regulatory interferences at the iron transporter ferroportin 1 (Fpn1) cause transient defects in iron homeostasis and erythropoiesis in polycythaemia (Pcm) mutant mice. The present study identified decreased Fpn1 expression in placental syncytiotrophoblast cells at late gestation as the mechanism of neonatal iron deficiency in Pcm mutants. Tissue specificity of embryonic Fpn1 dysregulation was ...

Paracoccidioidomycosis (PCM), caused by Paracoccidioides brasiliensis, is the most prevalent invasive fungal disease in South America. Systemic mycoses are the 10th most common cause of death among infectious diseases in Brazil and PCM is responsible for more than 50% of deaths due to fungal infections. PCM is typically treated with sulfonamides, amphotericin B or azoles, although complete erad...

Centrosomes are the main microtubule-organizing centers in animal cells. Centrosomes consist of a pair of centrioles surrounded by a matrix of pericentriolar material (PCM) that assembles from cytoplasmic components. In Caenorhabditis elegans embryos, interactions between the coiled-coil proteins SPD-5 and SPD-2 and the kinase PLK-1 are critical for PCM assembly. However, it is not known whethe...

Cells are surrounded by a hyaluronan-rich coat called 'pericellular matrix' (PCM), mainly constituted by hyaluronan, a long-chain linear polysaccharide which is secreted and resorbed by the cell, depending on its activity. Cell attachment to a surface is mediated by PCM before integrins and focal adhesions are involved. As hyaluronan is known to bear a negative charge at physiological pH, the r...

We describe a self-referencing interferometer in which the wavefront and its complex conjugate are generated in a Fabry-Perot cavity having one phase conjugate mirror (PCM). The finite response time of the PCM allows one to display momentarily the moiré between old and new interferograms after a sudden change has affected the input wavefront. Results using an externally pumped BaTiO(3) crystal ...

Model-based performance predictions and reconfigurations enable optimizing resource efficiency while ensuring that Quality-of-Service demands are met in today’s complex ITsystems. The Descartes Modeling Language (DML) and the Palladio Component Model (PCM) are two architectural performance modeling formalisms applied in this context. This paper compares DML to PCM concerning similarities, diffe...

Phase change material (PCM), placed in an exterior wall, alters the temperature profile within the wall and thus influences the heat transport through the wall. This may reduce the net energy transport through the wall via interactions with diurnal temperature swings in the external environment or reduce the electricity needed to meet the net load through the wall by shifting the time of the pe...

Paracoccidioidomycosis (PCM) is a systemic mycosis caused by the fungus Paracoccidioides brasiliensis and is endemic to Brazil. The aim of this study was to perform a retrospective analysis of the PCM cases in the countryside south of Rio Grande do Sul, Brazil. The files from four histopathology laboratories located in the city of Pelotas were obtained, and all of the epidemiological and clinic...

Human ES cells (hESCs) and human induced pluripotent stem cells (hiPSCs) are usually generated and maintained on living feeder cells like mouse embryonic fibroblasts or on a cell-free substrate like Matrigel. For clinical applications, a quality-controlled, xenobiotic-free culture system is required to minimize risks from contaminating animal-derived pathogens and immunogens. We previously repo...

Judea Pearl’s Causal Model is a rich framework that provides deep insight into the nature of causal relations. As yet, however, the Pearl Causal Model (PCM) has had a lesser impact on economics or econometrics than on other disciplines. This may be due in part to the fact that the PCM is not as well suited to analyzing structures that exhibit features of central interest to economists and econo...