Protein synthesis, the translation of mRNA into a polypeptide facilitated by the ribosome, is assisted by a variety of protein factors, some of which are GTPases. In addition to four highly conserved and well-understood GTPases with known function, there are also a number of noncanonical GTPases that are implicated in translation but whose functions are not fully understood. LepA/EF4 is one of ...

This article focuses on Quebec's most recent reform in the regionalization of health care to understand why the government chose to transform the regional boards into agencies. This case study used interviews and documentary analysis. Rooted in a political science perspective, the conceptual framework is inspired by the work of John Kingdon (1995) and draws on the four variables that influence ...

morphine’s effects on learning and memory processes are well known to depend on synaptic plasticity in the hippocampus. whereas the role of the hippocampus in morphine-induced amnesia and state-dependent learning is established, the biochemical and molecular mechanisms underlying these processes are poorly understood. the present study intended to investigate whether administration of morphine ...

T he great Midwestern flood of 1993 broke flow records along 1600 km of the Mississippi and Missouri rivers and caused up to $16 billion in damages (1, 2). Formal reviews of U.S. flood-control policy, both before and after the 1993 flood, concluded that the optimum strategy for reducing flood losses is to limit or even reduce infrastructure on floodplains. New emphases on flood-damage preventio...

introduction: apical transportation changes the physical shape and physiologic environment of the root canal terminus. the aim of the present experimental study was to determine the extent of apical transportation after instrumentation with hand k-flexofile and k3 rotary instruments by means of cone-beam computed tomography (cbct). methods and materials: forty mesiobuccal root canals of maxilla...

Mesenchymal stem cell (MSC) therapy is poised to establish a new clinical paradigm; however, recent trials have produced mixed results. Although MSC were originally considered to treat connective tissue defects, preclinical studies revealed potent immunomodulatory properties that prompted the use of MSC to treat numerous inflammatory conditions. Unfortunately, although clinical trials have met ...