Intracranial classic (WHO grade II) and anaplastic (WHO grade III) ependymomas are among the most common tumors in pediatric patients and have due to frequent recurrences and late relapses a relatively poor outcome. The impact of histopathological grading on patient outcome is controversial and therefore, molecular prognostic and predictive markers are needed to improve patient outcome. To date...

BACKGROUND Desmoid tumors (DTs) are rare mesenchymal lesions that can recur repeatedly. When it is feasible, DTs are surgically resected; however, this often results in high recurrence rates. Recently, treatment with PF-03084014, a potent γ-secretase inhibitor, has been shown to have antitumor activity in several tumor types by affecting the WNT/β-catenin pathway. Consequently, Notch pathway in...

Purpose: Head and neck squamous cell carcinomas exhibit variable sensitivity to inhibitors of the PI3K/mTOR pathway, an important target of genomic alterations in this cancer type. The mitogen-activated protein kinase kinase (MEK)/ERK/activator protein 1 (AP-1) and nuclear factor-kB (NF-kB) pathways are also frequently co-activated, but their roles in resistance mechanisms to PI3K/mTOR inhibito...

To lower the introduction and maintenance costs of autonomous power supplies for driving Internet-of-things (IoT) devices, we have developed low-cost Fe–Al–Si-based thermoelectric (FAST) materials generation modules. Our development approach combines computational science, experiments, mapping measurements, machine learning (ML). FAST a good balance mechanical properties excellent chemical stab...

apoptosis plays an important role in many pathological processes of the central nervous system. the neuroprotective effect of periodic fasting (pf) in contrast to severe fasting or starvation has been suggested. however, these beneficial effects seem to depend on the type and duration of the used feeding protocol. this study was designed to evaluate the effects of different pf protocols on the ...

In recent scenario many appliances requires DC power supply. Hence to obtain the DC power from input ac supply, Power Electronics circuits like Rectifiers which is a non-linear load has to be used. The current drawn by these non-linear load will be phase will not follow the supply voltage (i.e non sinusoidal). This results in a High Total Harmonic Distortion (THD) and Low Power Factor (PF). Hen...

Abstract Limited natural daylight in Nordic Countries means artificial lighting is a critical factor industrial plant production. The electricity cost of lights accounts for large percentage the overall optimal use production can be formulated as multi-objective problem (MOP) to achieve growth while minimizing cost. In previous work, solving this MOP, Genetic Algorithm (GA) was used create Pare...

Endometriosis is a chronic, painful condition with unknown etiology. A differential expression of microRNAs in the endometriotic tissues from women with endometriosis with pain compared to those without suggested a plausible role for miRNA or epigenetic mechanisms in the etiology of endometriotic pain. The peritoneal milieu is involved in maintenance of endometriotic lesion and nociception. We ...

BACKGROUND Pulmonary fibrosis (PF), cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) often cause chronic respiratory failure (CRF). METHODS In order to investigate if there are different patterns of adaptation of the ventilatory pump in CRF, in three groups of lung transplant candidates with PF (n=9, forced expiratory volume in 1 s (FEV(1))=37+/-3% predicted, forced vital...