A case of recent myocardial infarction in a 24-year-old man with no known history of Wolff—Parkinson— White syndrome is reported. The patient developed during sport training an exercise tachycardia associated with palpitation and syncope. The electrocardiogram, performed by rescue team, was suggestive of Wolff-Parkinson-White syndrome. He was admitted to Cardiovascular Diseases Institute for th...

OBJECTIVE We sought to determine the underlying cortical gene expression changes associated with Parkinson dementia using a next-generation RNA sequencing approach. METHODS In this study, we used RNA sequencing to evaluate differential gene expression and alternative splicing in the posterior cingulate cortex from neurologically normal control patients, patients with Parkinson disease, and pa...

In his 1817 ‘‘An Essay on the Shaking Palsy,’’ James Parkinson recorded many features of the condition that now bears his name (1). Parkinson emphasized the tremor at rest, flexed posture, festinating gait (Fig. 1), dysarthria, dysphagia, and constipation. Charcot and others later pointed out that the term paralysis agitans used by Parkinson was inappropriate, because in Parkinson’s disease (PD...

The prevalence of disordered communication is particularly high in individuals diagnosed with idiopathic Parkinson disease (IPD). At least 89% of these individuals have disordered speech and voice but only 3-4% received speech treatment. LSVT (Lee Silverman Voice Treatment) is a speech and voice treatment for individuals with Parkinson disease. It is the only speech treatment with Level one sho...

For several years our interest has been in a postural Parkinson-like tremor at 4-6/sec. which can be produced in the monkey by lesions of the central nervous system. We have also studied the effects of harmaline, a drug which evokes or intensifies the Parkinson-like tremor in lesioned animals and which also induces a fine, generalized tremor at 7-12/sec. in normal animals. The results obtained ...

Little is known about comorbidities of bipolar disorder such as Parkinson's disease. A case history and a literature survey indicate that bipolar disorder is linked with or influences Parkinson's disease and vice versa. Underlying mechanisms are poorly understood, and, more importantly, no treatment options are established in such double diagnoses. The few data in comorbid Parkinson cases seem ...

OBJECTIVE To report the clinical features and results of iodine I 123-2beta-carbomethoxy-3beta-(4-iodophenyl)-tropane (CIT) single photon emission computed tomography and molecular genetic analysis in a Korean woman with juvenile Parkinson disease with deletion in exon 4 of the parkin gene. DESIGN Case report with molecular genetic analysis. PATIENT AND RESULTS The patient had bradykinesia,...

T HE Wolff-Parkinson-White syndrome consists of an abnormally short P-R interval, usually prolonged duration of QRS complexes, and history of repeated episodes of paroxysmal tachycardia.' Variations of QRS complex have been observed during tachycardia, following exercise or atropine sulfate,1 or even while patients were at rest.2 The paroxysmal tachyeardias have been generally supraventricular,...

Sleep benefit in Parkinson's disease is characterized by restoration of mobility upon awakening from sleep and prior to drug intake. With this study, we aimed at assessing clinical and nocturnal sleep correlates of this phenomenon. We recorded motor and non-motor symptoms in 131 Parkinson patients with and without sleep benefit, as assessed by questionnaires. Polysomnography recordings were per...

A range of behaviors presumed to be related to aberrant or excessive dopaminergic medications are being increasingly recognized in Parkinson disease. These behaviors are linked by their incentiveor reward-based and repetitive natures and include pathological gambling, hypersexuality, compulsive shopping, compulsive eating, hobbyism, and compulsive medication use. Such behaviors can have potenti...