Motor speech disorders, including apraxia of speech (AOS), account for over 50% of the communication disorders following stroke. Given its prevalence and impact, and the need to understand its neural mechanisms, we used resting state functional MRI to examine functional connectivity within a network of regions previously hypothesized as being associated with AOS (bilateral anterior insula (aINS...

Exposure to airborne particulate matter (PM) is a world-wide health problem mainly because it produces adverse cardiovascular and respiratory effects that frequently result in morbidity. Despite many years of epidemiological and basic research, the mechanisms underlying PM toxicity remain largely unknown. To understand some of these mechanisms, we measured PM-induced apoptosis and necrosis in n...

In this series of studies, we determined the potential role of intracellular estrogen receptors (ER), ER and ER , on macrophage function in response to bacterial stimuli. The sex hormone 17 -estradiol (E2) and ER have been shown to modulate inflammatory responses as well as T helper cell type 1 (TH1)/TH2 responses. The mechanisms E2 and its receptors use to alter these immune functions remain l...

Stem cell number in shoot and floral meristems of Arabidopsis (Arabidopsis thaliana) is regulated by the CLAVATA3 (CLV3) signaling pathway. Perception of the CLV3 peptide requires the receptor kinase CLV1, the receptor-like protein CLV2, and the kinase CORYNE (CRN). Genetic analysis suggested that CLV2 and CRN act together and in parallel with CLV1. We studied the intracellular localization of ...

In this paper, a particular actuation singularity of a 3-RPS symmetrical rotational parallel mechanism (PM) is studied. When the movable platform of this PM is restricted to rotate about the vertical axis of the base, it is equivalent to a single loop mechanism (SLM). By analyzing the constraint properties of the SLM, the motion characteristics of this 3-RPS rotational PM under this motion are ...

The change of market and the explosion of product variety have led to increased automation and the need for complex equipment. Therefore, the reliability and the maintainability of the equipment play an important role in controlling both the quantity and quality of the products. In order to ensure specified availability and reliability of production process, preventive maintenance (PM) should b...

A method and technical tools for correction of range-bias caused by variation of photo-multiplier (PM) output pulses in amplitude and shape are considered. The method is based on preliminary estimation of a relationship between certain integral parameter of PM pulses and corresponding range-bias. This integral parameter is measured for each PM pulse in parallel with measurement of basic time in...

This paper describes a compiler that generates both hardware and controlling software for eld-programmable compute accelerators. By analyzing a source program together with part of its input, the compiler generates VHDL descriptions of functional units that are mapped on a set of FPGA chips and an optimized sequence of control instructions that run on the customized machine. The primary techniq...

Previous studies on prospective memory (PM), defined as memory for future intentions, suggest that psychological stress enhances successful PM retrieval. However, the mechanisms underlying this notion remain poorly understood. We hypothesized that PM retrieval is achieved through interaction with autonomic nervous activity, which is mediated by the individual accuracy of interoceptive awareness...

The 3 Akt protein kinase isoforms have critical and distinct functions in the regulation of metabolism, cell growth, and apoptosis, yet the mechanisms by which their signaling specificity is achieved remain largely unclear. Here, we investigated potential mechanisms underlying Akt isoform functional specificity by using Akt2-specific regulation of glucose transport in insulin-stimulated adipocy...