Although there are currently 62 mutants of Cx43 (connexin43) that can cause ODDD (oculodentodigital dysplasia), only two mutants have also been reported to cause palmar plantar hyperkeratosis. To determine how mutants of Cx43 can lead to this skin disease, REKs (rat epidermal keratinocytes) were engineered to express an ODDD-associated Cx43 mutant always linked to skin disease (fs260), an ODDD-...

A 20-year-old woman presented to our clinic with a history of fissuring, cracking and scaling of her lips that had been present for about 2 months. The lesions started at the corners of the mouth and insidiously migrated towards the centre, involving both lips completely. She complained of a burning sensation and severe discomfort during eating and speaking. She had been prescribed various medi...

Presented herein are 18 cases of erythematous, scaly papules or plaques with microscopic features of both seborrheic keratosis and psoriasis. There was, however, no known clinical diagnosis of psoriasis in any patient, neither at initial presentation nor on follow-up examination. Most lesions were solitary, present for 6-7 months, and identified on the upper or lower extremities. Other sites in...

and grains, hyperkeratosis, and parakeratosis. Both present clinically with hyperkeratotic papules andwarty plaques but differ in their ageofonset andassociatedabnormalities.ADEN is often congenital, while DD typically manifests in the second or third decade of life. Typically, DD has associated nail abnormalities, mucous membrane involvement, palmoplantar pits, and punctate keratoses, while AD...

BACKGROUND Vulvar dermatoses are often difficult to classify due to histopathologic overlap. We aimed to report our experience at a single institution. METHODS A total of 183 non-neoplastic, non-infectious vulvar biopsies were reviewed. Associations between histopathologic features and specific diagnoses were analyzed by Chi-squared tests. RESULTS Twenty-two biopsies (12.0%) showed two conc...

INTRODUCTION The aims of the present study were to identify histopathological parameters which are linked to local clinical skin disease at two distinct anatomical sites in systemic sclerosis (SSc) patients with skin involvement (limited cutaneous systemic sclerosis (lcSSc) or diffuse cutaneous systemic sclerosis (dcSSc)) and to determine the sensitivity of SSc specific histological alterations...

A 59-year-old male visited our department, complaining of red itchy papules on his right lower leg. Initially, the papules appeared on the dorsum of his right foot, and spread upwards to the shin. He had no infectious symptoms, such as throat pain and fever, prior to the development of the dermatosis. Physical examination revealed that a number of reddish papules and erythematous lesions with s...

This study was carried out for the isolation and identification of Avibacterium paragallinarum, the etiological agent of infectious coryza (IC). Pathological changes were also investigated that occurred in organs in layer chickens obtained from some selected areas of Bangladesh. A nasal swabs (n=30) from dead chickens and four swabs from live chickens were collected aseptically. The organisms f...

Zinc content of testes, bones, esophagus, kidneys, and muscles was decreased, whereas iron content was increased in the testes of zinc-deficient rats compared to restrictedly fed control rats. Histochemical enzyme determinations revealed reduced activities of certain enzymes in the testes, bones, esophagus, and kidneys. In the testes, lactic dehydrogenase (LDH), malic dehydrogenase (MDH), alcoh...

The objectives of this experiment were to determine effects of reducing particle size on growth performance, carcass characteristics, stomach morphology, and VFA concentration in the hindgut of growing-finishing pigs if diets were formulated to a constant ME. Thirty-six gilts and 36 barrows (32.00 ± 1.58 kg initial BW) were individually penned and randomly allotted to 4 dietary treatments in a ...