N-Butyl-N-(4-hydroxybutyl)nitrosamine (BBN) is a potent carcinogen in the urinary bladder of animals. The BBN model of bladder cancer is an excellent model of human urinary bladder cancer and has already led to a greater knowledge of its pathogenesis. In our studies, histogenesis and morphological characteristics of BBN urinary bladder cancer were analyzed in different animal species such as ra...

In trachomatous areas a large percentage of patients with glaucoma also show signs of trachoma. The WHO (I 956) defined trachoma as a specific communicable keratoconjunctivitis, usually of chronic evolution, characterized by the formation of follicles, papillary hyperplasia, and pannus, and typically leading to scar formation. Contradictory reports have appeared in the literature regarding the ...

Ectopic thyroid tissue is an uncommon embryologic aberration characterized by the presence of thyroid tissue in a site other than its usual pre-tracheal location. Single ectopic thyroid tissue is the most common variant, and the base of the tongue is the most frequent ectopic location. Dual ectopic thyroid is extremely rare, and only eleven cases have been reported in the English literature. Fu...

The effect of dietary orotic acid (OA) in liver-pancreas carcinogenesis induced in female Syrian hamsters by N-Nitroso(2-hydroxypropyl) (2oxopropyl)amine (HPOP) was evaluated. All animals infused with the carcinogen received the same doses. ReSUlts of the control group which received no OA or carcinogen were compared with the results of: (a) hamsters treated with HPOP and fed a regular 20% prot...

Verrucous papillary lesions (VPLs) of oral cavity are diagnostically challenging as they include a spectrum of benign, potentially malignant, and frankly malignant lesions. A majority of the benign VPLs have viral aetiology and include commonly occurring squamous papilloma along with verruca vulgaris, focal epithelial hyperplasia, and condyloma. Current understanding of potentially malignant VP...

Papillomatosis is a relatively common (22%) benign microscopic lesion in the breast and rarely seen in women less than 30 years old. It is a papillary proliferation of the ductal epithelium which partly fills up smaller ducts and to degree distends them. The histological classification of this entity is controversial because similar or identical lesions have been classified using different term...

In trachomatous areas a large percentage of patients with glaucoma also show signs of trachoma. The WHO (I 956) defined trachoma as a specific communicable keratoconjunctivitis, usually of chronic evolution, characterized by the formation of follicles, papillary hyperplasia, and pannus, and typically leading to scar formation. Contradictory reports have appeared in the literature regarding the ...

Abstract Introduction/Objective Papillary breast lesions are comprised of a broad spectrum entities ranging from benign conditions like intraductal papilloma to invasive carcinoma. These account for less than 3% percent tumors and 2% malignancies. The wide range overlap in the clinical, imaging, histologic characteristics these can often make them difficult classify. Here we present case challe...

It has been shown that the occurrence of the preneoplastic lesion, papillary or nodular hyperplasia (PN hyperplasia) in rat urinary bladder induced by carcinogens is correlated with that of cancer. Therefore, the promoting effects of chemicals in two-stage bladder carcinogenesis were judged by measuring their ability to induce PN hyperplasia in rats. Male rats were given N-butyl-N-(4-hydroxybut...