BACKGROUND Subacute cutaneous lupus erythematosus (SCLE) can be induced by numerous drugs. We report 3 cases of SCLE induced by proton pump inhibitors (PPIs). OBJECTIVE To highlight a rare cutaneous side effect induced by a frequently prescribed drug such as a PPI. CASE REPORTS Case 1 was a 30-year-old man who developed multiple annular plaques over the trunk and lower limbs 1 month after t...

Achieving the optimal clinical response for patients with upper gastrointestinal peptic disease is important. This response depends on the pathology treated as well as on the choice of proton pump inhibitor. Here, we identify factors in specific disease therapy and proton pump inhibitor (PPI) pharmacokinetic and pharmacodynamic characteristics that help us achieve this goal. These include diffe...

Spectrophotometric method for the determination of certain proton pump inhibitors belonging to the benzimidazole class of compounds has been developed. The method is based on the reaction of omeprazole, lansoprazole, pantoprazole, rabeprazole and esomeprazole with iron (III) and subsequent reaction with ferricyanide under neutral condition which yields Prussian blue product with maximum absorpt...

A stability-indicating high-performance liquid chromatographic (HPLC) method was developed with short run time and validated for the assay of process related impurities of pantoprazole in bulk form. Resolution of drug, its potential impurities and degradation products were achieved on a Hypersil ODS column utilizing a gradient with 0.01 M phosphate buffer of pH 7 and acetonitrile as eluent, at ...

The human clearance of proton pump inhibitors (PPIs) of the substituted benzimidazole class is conducted primarily by the hepatic cytochrome P450 (P450) system. To compare the potency and specificity of the currently used PPIs (i.e., omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole) as inhibitors of four cytochrome P450 enzymes (CYP2C9, 2C19, 2D6, and 3A4), we performed in ...

Jul 1, 2011 . The oral acid suppressors famotidine and omeprazole have been widely used. To facilitate dosing, the omeprazole paste was combined with . with H2RAs, such as ranitidine or famotidine, 30–60 minutes prior to a meal would be a standard dose omeprazole, pantoprazole, or lansoprazole in more. Feb 25, 2015 .

Nanoparticles are a promising medication delivery method that can deliver drugs in controlled and targeted manner. They're made to release the medicine close proximity target tissue. Solid lipid nanoparticles (SLNs) new type of submicron-sized emulsion which solid replaces liquid (oil). The goal this study was create (SLN) containing pantoprazole (a proton pump inhibitor) improve drug's entrapm...

Effects of egg york containing IgY specific for Helicobacter pylori on the bacterial growth and intragastric infection were investigated in comparison with a proton-pump inhibitor pantoprazole. For in vitro anti-bacterial activity test, H. pylori (1×10(8) CFU/mL) was incubated with a serially diluted IgY for 3 days. As a result, IgY fully inhibited the bacterial growth at 16 mg/mL, which was de...