نتایج جستجو برای: pancreatic β cell

تعداد نتایج: 1877157  

2014
Raffaella Mormile

Type 1 diabetes (T1D) is a T-cell mediated autoimmune disease characterized by the destruction of pancreatic β-cells leading to absolute insulin deficiency [1]. Exogenous insulin represents the core of therapy for T1D that is fatal unless treated[2]. Several years of progressive autoimmune β-cells damage generally precede the clinical onset of diabetes [2]. Moreover, it has been found that the ...

2017
Jarrett R. Remsberg Benjamin N. Ediger Wesley Y. Ho Manashree Damle Zhenghui Li Christopher Teng Cristina Lanzillotta Doris A. Stoffers Mitchell A. Lazar

OBJECTIVE Histone deacetylases are epigenetic regulators known to control gene transcription in various tissues. A member of this family, histone deacetylase 3 (HDAC3), has been shown to regulate metabolic genes. Cell culture studies with HDAC-specific inhibitors and siRNA suggest that HDAC3 plays a role in pancreatic β-cell function, but a recent genetic study in mice has been contradictory. H...

2017
Sudhir G. Tattikota Thomas Rathjen Sarah J. McAnulty Hans-Hermann Wessels Ildem Akerman Martijn van de Bunt Jean Hausser Jonathan L.S. Esguerra Anne Musahl Amit K. Pandey Xintian You Wei Chen Pedro L. Herrera Paul R. Johnson Donal O’Carroll Lena Eliasson Mihaela Zavolan Anna L. Gloyn Jorge Ferrer Ruby Shalom-Feuerstein Daniel Aberdam Matthew N. Poy

Pancreatic β cells adapt to compensate for increased metabolic demand during insulin resistance. Although the microRNA pathway has an essential role in β cell proliferation, the extent of its contribution is unclear. Here, we report that miR-184 is silenced in the pancreatic islets of insulin-resistant mouse models and type 2 diabetic human subjects. Reduction of miR-184 promotes the expression...

2013
José Francisco López-Acosta José Luis Moreno-Amador Margarita Jiménez-Palomares Ana R. Díaz-Marrero Mercedes Cueto Germán Perdomo Irene Cózar-Castellano

There is an urgency to find new treatments for the devastating epidemic of diabetes. Pancreatic β-cells viability and function are impaired in the two most common forms of diabetes, type 1 and type 2. Regeneration of pancreatic β-cells has been proposed as a potential therapy for diabetes. In a preliminary study, we screened a collection of marine products for β-cell proliferation. One unique c...

2017
Jamie Trott Ee Kim Tan Sheena Ong Drew M. Titmarsh Simon L.I.J. Denil Maybelline Giam Cheng Kit Wong Jiaxu Wang Mohammad Shboul Michelle Eio Justin Cooper-White Simon M. Cool Giulia Rancati Lawrence W. Stanton Bruno Reversade N. Ray Dunn

Pluripotent stem cells have been proposed as an unlimited source of pancreatic β cells for studying and treating diabetes. However, the long, multi-step differentiation protocols used to generate functional β cells inevitably exhibit considerable variability, particularly when applied to pluripotent cells from diverse genetic backgrounds. We have developed culture conditions that support long-t...

2012
Hannah Seok Bong Soo Cha

Corresponding author: Bong Soo Cha Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea E-mail: bscha@yuhs.ac We sincerely appreciate the interest and comments regarding our study, “Balsamic Vinegar Improves High Fat-Induced Beta Cell Dysfunction via Beta Cell ABCA1,” which was published in Diabetes & Metabolism Journal 2012;36...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2015
Murray Korc

Diabetes may be a consequence of pancreatic cancer, preceding cancer diagnosis. The underlying mechanism is the release of exosomes delivering adrenomedullin to β cells, inducing endoplasmic reticulum stress and perturbations in the unfolded protein response, leading to β-cell dysfunction and death. This knowledge could lead to improved diagnostic strategies for pancreatic cancer.

Journal: :International journal of oncology 2015
Shaojie Jiang Lina Zhu Haimei Tang Miaofeng Zhang Zhihua Chen Jian Fei Baosan Han Gang-Ming Zou

Apurinic/apyrimidinic endonuclease 1/redox factor-1 (Ape1/Ref-1, Ape1) is a multifunctional protein that is upregulated in human pancreatic cancer. Ape1 redox domain plays an essential role in regulating the effects of reactive oxygen species (ROS) generated during physiological metabolism and pathological stress. In the present study, we explored whether Ape1 and ROS affect WNT/β-catenin signa...

2017
Zongzhe Jiang Jingjing Tian Wenjian Zhang Hao Yan Liping Liu Zhenhe Huang Jinning Lou Xiaosong Ma

Our colleagues have reported previously that human pancreatic progenitor cells can readily differentiate into insulin-containing cells. Particularly, transplantation of these cell clusters upon in vitro induction for 3-4 w partially restores hyperglycemia in diabetic nude mice. In this study, we used human fetal pancreatic progenitor cells to identify the forkhead protein FoxO1 as the key regul...

2015
Tomokazu Matsuda Hiroaki Takahashi Yusuke Mieda Shinobu Shimizu Takeshi Kawamoto Yuki Matsuura Tomoko Takai Emi Suzuki Ayumi Kanno Maki Koyanagi-Kimura Shun-ichiro Asahara Alberto Bartolome Norihide Yokoi Hiroshi Inoue Wataru Ogawa Susumu Seino Yoshiaki Kido Marc Claret

During the development of type 2 diabetes, endoplasmic reticulum (ER) stress leads to not only insulin resistance but also to pancreatic beta cell failure. Conversely, cell function under various stressed conditions can be restored by reducing ER stress by activating AMP-activated protein kinase (AMPK). However, the details of this mechanism are still obscure. Therefore, the current study aims ...

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