Pancreatic cancer is the fifth leading cause of cancer death in the United States. We used cDNA microarrays to analyze global gene expression patterns in 14 pancreatic cancer cell lines, 17 resected infiltrating pancreatic cancer tissues, and 5 samples of normal pancreas to identify genes that are differentially expressed in pancreatic cancer. We found more than 400 cDNAs corresponding to genes...

BACKGROUND To establish a model of pancreatic cancer induced by 7,12-dimethylbenzantracene (DMBA) in Sprague-Dawley (SD) rats, and detect the expression of DNA-repair proteins (MGMT, ERCC₁, hMSH₂, and hMLH₁) and their significance in pancreatic cancer and non-cancerous pancreatic tissues of SD rats. METHODS DMBA was directly implanted into the parenchyma of rat pancreas (group A and group B),...

The reliable and effective automation of biomedical therapies is the need hour for medical professionals. A model predictive controller (MPC) has ability to handle complex dynamic systems involving multiple inputs/outputs, such as systems. This article firstly presents a literature review MPCs followed by survey research reporting MPC-enabled some therapies. includes their evolution, architectu...

saffron, the dried red-orange stigmas of crocus sativus l, has been known as a flavoring agent, food coloring and traditional herbal medicine. pharmacological effects of saffron are mainly attributed to crocin, crocetin, picrocrocin and safranal. these components especially crocin, have significant effects including antidepressant and anticonvulsant, analgesic, anti-cancer and other therapeutic...

Over 4000 flavonoids have been identified so far and among these, many are known to have antitumor activities. The basis of the relationships between chemical structures, type and position of substituent groups and the effects these compounds exert specifically on cancer cells are not completely elucidated. Here we report the differential cytotoxic effects of two flavone isomers on human cancer...

BACKGROUND Activation of embryonic signaling pathways quiescent in the adult pancreas is a feature of pancreatic cancer (PC). These discoveries have led to the development of novel inhibitors of pathways such as Notch and Hedgehog signaling that are currently in early phase clinical trials in the treatment of several cancer types. Retinoid signaling is also essential for pancreatic development,...

endocrine tumors of the pancreas (islet-cell tumors) are rare with neuroendocrine origin. the patient was a 41- year- old man, admitted with chief complains of epigastric mass feeling, dull abdominal pain, lack of appetite and weight loss up to 2-3 kg since 6 months ago. in physical examination, a mass was detected in epigaster and left upper quadrant (luq). in abdominal x-ray, a calcified mass...

background : pancreas as the insulin-producing gland is subjected to destruction and change in the diabetes-producing process. realtime sonography can assess the gland in 95% of cases and its accuracy in diagnosis of pancreatic disease matches that of ct-scan. the purpose of this study was to evaluate pancreatic diameter and echogenicity by sonography and to examine the correlation of these two...