UNLABELLED The cellular innate immune system recognizing pathogen infection is essential for host defense against viruses. In parallel, viruses have developed a variety of strategies to evade the innate immunity. The hepatitis B virus (HBV), a DNA virus that causes chronic hepatitis, has been shown to inhibit RNA helicase RIG-I-mediated interferon (IFN) induction. However, it is still unknown w...

background & aims of the study: in the tropical regions of iran, scorpionism is one of the important medical and public concerns. poisoning with scorpion sting is one of the life threatening medical emergencies especially in individuals who are less than 6 years; knowing about its epidemiologic aspects might lead to exploit appropriate preventive methods. therefore, for this purpose, the epidem...

Hymenoptera stings can cause serious injury to humans. We report the clinical findings of 6 cases of Hymenoptera stings. All patients developed painful erythematous papules at the sting sites and had a past history of parasitoid wasp sting. This is the first clinical report of the parasitoid wasp, Cephalonomia gallicola, causing human stings in Korea.

Natural immunity, the first line for body to defense against invasion of pathogen, serves as body’s perception presence pathogens depends on nucleic acid recognition mechanisms. The cyclic GMP-AMP synthase-stimulator interferon gene (cGAS-STING) signaling pathway is considered an essential pattern and effector in natural immune system mainly responsible recognizing DNA molecules present cytopla...

Hymenoptera venom allergy is a potentially life-threatening allergic reaction following a honeybee, vespid, or ant sting. Systemic-allergic sting reactions have been reported in up to 7.5% of adults and up to 3.4% of children. They can be mild and restricted to the skin or moderate to severe with a risk of life-threatening anaphylaxis. Patients should carry an emergency kit containing an adrena...

468 Urticarial Vasculitis After Bee-sting Therapy June-Hyuk Lee, Sung Woo Park, An-Soo Jang, DoJin Kim, and ChoonSik Park. Respiratory and allergy, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea; Division of Respiratory and Allergy Medicine, Soonchunhyang University Hospital, College of Medicine, Bucheon, South Korea. Background: Bee-sting therapy is one of the oriental traditi...

background and purpose: scorpion sting is one of the major health problems of undeveloped countries, which causes severe complications and sometimes death.this study aimed toassessment knowledge of scorpion sting patients who admitted to ahvaz razi hospital about pre-hospital care. materials and methods: this is a descriptive study, which its participants were sampled by a pilot method, and the...

Scorpion stings are a public health problem in south and southwest Iran. There is little information regarding climatological effects on incidence of scorpion stings in Iran. Therefore, the present systemic survey of scorpion sting data was conducted from the point of view of entomo-meteorological relationships and analyzed statistically for the Dezful area in Khuzestan, southwest of Iran. The ...

We report on a 33-year-old female patient with indolent systemic mastocytosis and urticaria pigmentosa who died of an anaphylactic reaction after a yellow jacket sting. As she had no history of previous anaphylactic sting reaction, there was no testing performed in order to detect hymenoptera venom sensitization. But even if a sensitization had been diagnosed, no venom immunotherapy (VIT) would...

Autoimmune disorders constitute a major and growing health concern. However, the genetic and environmental factors that contribute to or exacerbate disease symptoms remain unclear. Type I interferons (IFNs) are known to break immune tolerance and be elevated in the serum of patients with autoimmune diseases such as lupus. Extensive work over the past decade has characterized the role of a prote...