نتایج جستجو برای: pah
تعداد نتایج: 7545 فیلتر نتایج به سال:
215 interleukin 6, the expression of which is also modulated by BMPR2.5 The currently enrolling clinical trials in PAH with molecules such as FK506, rituximab, and anakinra selectively targeting the immune system are promising. In the study by Jasiewicz et al.,3 10 patients were incident cases who received PAH-targeted therapy at entry to the study. It would be interesting to see whether the le...
OBJECTIVE Germline mutations in the bone morphogenetic protein receptor type-2 (BMPR2) gene are considered to be a major risk factor for pulmonary arterial hypertension (PAH). BMPR2 mutations have been reported in 10%-20% of idiopathic PAH and in 80% of familial PAH cases. The aim of this study was to evaluate the frequency of mutations in the serine/threonine kinase domain of the BMPR2 gene in...
Pulmonary hypertension (PH) is found in a vast array of diseases, with a minority representing pulmonary arterial hypertension (PAH). Idiopathic PAH or PAH in association with other disorders has been associated with poor survival, poor exercise tolerance, progressive symptoms of dyspnea, and decreased quality of life. Left untreated, patients with PAH typically have a progressive decline in fu...
Alfalfa, tall fescue, ryegrass, and celery, some of which were inoculated with the AM fungus Glomus intraradices, were compared for their contributions to phenanthrene (PHE), pyrene (PYR), and dibenzo(a,h)anthracene (DBA) dissipation in spiked soil. A pot experiment was conducted in which PAHs extracted from soil and plant, quantity of PAH degraders, and plant biomass were evaluated. The result...
Pulmonary arterial hypertension (PAH) is a devastating disease in which remodeling of the small pulmonary arteries leads to a progressive increase in pulmonary vascular resistance and right-sided heart failure. Over the past decade, new treatments for PAH, such as the use of ERAs, PDE-5 inhibitors and prostacyclin analogs, have brought about dramatic improvements in clinical outcomes. Epoproste...
Depending on their origins, polycyclic aromatic hydrocarbons (PAH) are characterized by different chemical properties. Petrogenic PAH (e.g. from fossil fuels) and pyrolytic PAH (e.g. those produced by incineration processes) are therefore expected to affect organisms differently. The impact of trophic exposure to these PAH was investigated on swimming and metabolic performance of zebrafish Dani...
Mutation analysis in a patient with mild hyperphenylalaninaemia showed three distinct base substitutions in exon 12 of the phenylalanine hydroxylase (PAH) gene. All three mutations, R413P, Y414C, and D415N, have previously been described as being independently associated with PAH deficiency. Family studies and independent analysis of the PAH alleles of the patient showed cosegregation of the R4...
Abstract Background Pulmonary arterial hypertension (PAH) is characterized by the remodeling of pulmonary arteries, with an increased pressure and right ventricle (RV) overload. Until now, there still a lack effective treatment applied. Experimental research has reported beneficial effects mesenchymal stem cells (MSCs) therapy in PAH. However, are few studies on human umbilical cord (hUC-MSCs) ...
RATIONALE Polycyclic aromatic hydrocarbons (PAHs) are nonpolar and difficult to detect by desorption electrospray ionization. We present a new detection method based on cationization with silver ions, which has the added advantage of being able to differentiate PAHs with the same mass but different structure. METHODS 9,10-Diphenylanthracene and triptycene, in addition to four different groups...
BACKGROUND Pulmonary arterial hypertension (PAH) is a leading cause of mortality in systemic sclerosis (SSc). We sought to determine survival, predictors of mortality, and health-related quality of life (HRQoL) related to PAH in a large SSc cohort with PAH. METHODS We studied consecutive SSc patients with newly diagnosed (incident) World Health Organization (WHO) Group 1 PAH enrolled in a pro...
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