Trehalose-6-phosphate phosphatase (TPP) is an essential enzyme for growth of mycobacteria, which has been identified to be a potential anti-tuberculosis drug target. However, the biochemical and ligand-binding properties and the 3D structure of TPP remain unclear so far. In the present study, we expressed the recombinant TPP protein from Mycobacterium tuberculosis (otsB2/Rv3372). Results from t...

Observatory (iSERVO; www.iservo. edu.au) is a planned partnership of primarily Asia Pacific economies interested in studying, forecasting, and mitigating the damaging effects of large and great earthquakes as well as the tsunamis they produce. The iSERVO concept is founded on the use of modern information technology to simulate the nonlinear dynamical earthquake and tsunami processes at all rel...

At present, the WTO's multilateral trading system faces acute challenge of adapting to digital and commercial economies' rapid evolution. The recent regional trade agreements embody corresponding achievements Comprehensive Progressive Agreement for Trans-Pacific Partnership (CPTPP), Economic (EPA), United States Mexico Canada (USMCA) in facilitating free flow data regulating barriers trade. Gen...

Abstract This study aims to determine the effectiveness of supplementation sodium (Na) alginate Sargassum sp. from Lampung waters enhance non-specific immune response and resistence Pacific white shrimp ( Litopenaeus vannamei ) against spot disease. used a completely randomized design with 3 treatments, namely feeding without (A) or control, dietary Na at dose 2.0 (B), 4.0 g kg −1 feed (C), eac...

Although delocalized lipophilic cations have been identified as effective cellular and mitochondrial carriers for a range of natural and synthetic drug molecules, little is known about their effects on pharmacological properties of peptides. The effect of triphenylphosphonium (TPP) cation on bioactivity of antioxidant tetrapeptides based on the model opioid YRFK motif was studied. Two tetrapept...

The measurement of tubal perfusion pressures (TPP) is a recent advance in the field of gynaecoradiology. Measurement of TPP involves a standardized technique using transcervically placed tubal catheters which is reviewed in detail. TPP assesses the functional status of the Fallopian tubes, i.e. their ability to permit pregnancy. Infertile patients with normal TPP demonstrated a higher pregnancy...

New Zealand's Pharmaceutical Management Agency (PHARMAC) has been highly successful in facilitating affordable access to medicines through a combination of aggressive price negotiations, innovative procurement mechanisms, and careful evaluation of value for money. Recently the US government, through the establishment of a series of bilateral and plurilateral "free" trade agreements, has attempt...

Seismic anisotropy is an efficient way to investigate the deformation field within the upper mantle. In the framework of rigid tectonic plates, we make use of recent tomographic models of azimuthal anisotropy for deriving the best rotation pole of the Pacific plate in the uppermost 200km of the mantle. It is found to be in good agreement with current plate motion (NUVEL1, HS3 and NNR). However,...

PURPOSE Tetraphenylphosphonium (TPP+) is a permeant lipophilic cation that accumulates in cultured cells and tissues as a function of the electrical membrane potential across the plasma membrane. This study was undertaken to determine whether TPP+ can be used for assessing membrane potential in intact lenses in organ culture. METHODS Rat lenses were cultured in media containing 10 microM TPP+...