The transcription factor Sp1 was previously shown to undergo proteasome-dependent degradation when cells were glucose-starved and stimulated with the adenylate cyclase inducer, forskolin. However, the control of the Sp1 degradation process is largely unknown. Using in vitro and in vivo interaction studies, we show in the present study that Sp1 interacts with human Sug1 [hSug1, also known as p45...

Macrophages are located around hair follicles in normal skin and typically peak density during the mid-telogen stage of cycle. Hair chemotactically attract macrophages T cells range to regulate follicle stem (HFSCs) quiescence, proliferation, differentiation physiologic injured states. The expression fractalkine receptor CX3CR1 has been identified as a key regulator macrophage cell migration fu...

Listeria monocytogenes is a ubiquitous gram-positive, rod-shaped, widespread in nature, facultative intracellular human and animal pathogen that causes infections collectively termed listeriosis. L. monocytogenes EGD encodes a total of 133 surface proteins, the abundance of which, as well as the variety of anchoring systems, probably reflects the ability of this bacterium to survive in diverse ...

Two-hybrid screening of a tobacco BY-2 cell suspension cDNA library using the p43(Ntf6) mitogen-activated protein (MAP) kinase as bait resulted in the isolation of a cDNA encoding a protein with features characteristic of a MAP kinase kinase (MEK), which has been called NtMEK1. Two-hybrid interaction analysis and pull-down experiments showed a physical interaction between NtMEK1 and the tobacco...

Resveratrol is a natural phenol with protective effects against cancer and inflammation-related diseases. Its mechanism of action involves the activation of nuclear factor E2 p45-related factor 2 (Nrf2), which plays a key role in regulation of genes driven by antioxidant response element (ARE). Inspired by the effect of resveratrol, here we synthesized a series of imine resveratrol analogs (IRA...

Extensive Descemet membrane detachment (DMD) is a rare complication of intraocular surgery that can lead to corneal decompensation. Although DMD may resolve spontaneously, surgical repair frequently is required. The diagnosis may be difficult because corneal edema can obscure visualization of the Descemet membrane (DM). Ultrasonographic biomicroscopy (UBM) has been the standard for imaging DMD ...