More reliable and faster prediction methods are needed to interpret enormous amounts of data generated by sequencing and genome projects. We have developed a new computational tool, PON-P2, for classification of amino acid substitutions in human proteins. The method is a machine learning-based classifier and groups the variants into pathogenic, neutral and unknown classes, on the basis of rando...

The effects of ATP on salivary glands have been recognized since 1982. Functional and pharmacological studies of the P2 nucleotide receptors that mediate the effects of ATP and other extracellular nucleotides have been supported by the cloning of receptor cDNAs, by the expression of the receptor proteins, and by the identification in salivary gland cells of multiple P2 receptor subtypes. Curren...

The antibody and cell mediated immune responses were investigated in inbred Lewis rats with experimental allergic neuritis (EAN) induced by either P2, a protein purified from the bovine cauda equina nerve roots, or whole bovine nerve root myelin. In the P2 immunised animals both antibodies to P2 detected by radioimmunoassay and cell-mediated immunity to P2 assayed by skin testing appeared befor...

Phosphatidyl inositol 4,5-bisphosphate (PI 4,5-P2) accumulates in a Rac/Rop-dependent manner in the pollen tube tip plasma membrane, where it may control actin organization and membrane traffic. PI 4,5-P2 is hydrolyzed by phospholipase C (PLC) activity to the signaling molecules inositol 1,4,5-trisphosphate and diacyl glycerol (DAG). To investigate PLC activity during tip growth, we cloned Nt P...

This study aimed to determine the effect of giving various doses fermented cassava peel by local microorganisms (MOL) on percentage carcasses male sheep. The research was carried out at Mr. Praditya Raharja's Ranch, Jalan Bunga Rinte, Simpang Selayang, Medan, from December 16, 2019 March 8, 2020 using a completely randomized design (CRD) with 4 treatments and 5 replications. used 20 sheep an av...

Let P1 and P2 be two finite sets of points in the plane, so that P1 is contained in a line l1, P2 is contained in a line l2, and l1 and l2 are neither parallel nor orthogonal. Then the number of distinct distances determined by the pairs of P1 × P2 is Ω (

milk thistle is used traditionally as a hepaprotective agent and supportive treatment of liver disorders. the most problems in milk thistle harvest are tall height, seed shedding and being spinous. in this trial, effects of 3 native populations (p1: isfahan violet flower, p 2: ahvaz white flower and p3: ahvaz violet flower) and 3 topping levels (t1:control, t2: topping in 7 leaves stage and t3:...

background : we conducted a retrospective analysis to evaluate overall survival (oas) and disease free survival (dfs) rates in patients with squamous cell carcinoma of the urinary bladder according to different prognostic factors. methods : this retrospective study analyzed the medical records of patients with non-metastatic squamous cell carcinoma of the urinary bladder. all men underwent radi...