We suggest a novel, parametric, approach to estimating the significance of the output of motif finders. Specifically, we rely on the good fit we observe between the 3-parameters Gamma family and the null distribution of motif scores. This fit was observed across multiple motif finders, background models and scoring functions. Under this parametric assumption we compute and show the utility of a...

هدف: سطوح بالای همیاری در جوامعی شکل می­ گیرد که آن افرادی از هنجارهای خاصی تخطی کنند، با رفتار تنبیهی دیگران مواجه شوند. هدف مطالعه حاضر تفکیک انواع واکنش افراد به پیشهادهای ناعادلانه و بررسی مولفه­ های الکتروفیزیولوژیک آنان بود. روش: 40 نفر جنسیت مذکر دانشجویان دانشگاه شهید بهشتی طریق نمونه گیری دسترس این شرکت کردند آنها اصلاح­ شده بازی ­های دیکتاتور اولتیماتوم مورد سنجش ارزیابی قرار گرفت. یا...

Recently we proposed a novel two-step approach to test for pathway effects in disease progression. The goal of this approach is to study the joint effect of multiple single-nucleotide polymorphisms that belong to certain genes. By using random effects, our approach acknowledges the correlations within and between genes when testing for pathway effects. Gene-gene and gene-environment interaction...

While it is often argued that a p-value is a probability; see Wasserstein & Lazar (2016), we argue that a p-value is not defined as a probability. A p-value is a bijection of the sufficient statistic for a given test which maps to the same scale as the type I error probability. As such, the use of p-values in a test should be no more a source of controversy than the use of a sufficient statisti...

How much more evidence is there in a ‘highly significant’ p-value of 0.01 relative to one ‘just significant’ at 0.05? Why does the replication of an experiment lead, on average, to a higher p-value than the one just obtained? To answer such questions one must go beyond the traditional p-value which is conditional on the data and thus interpretable only in the context of the experiment just perf...

We consider the problem of testing each of m null hypotheses with a sequential permutation procedure in which the number of draws from the permutation distribution of each test statistic is a random variable. Each sequential permutation p-value has a null distribution that is nonuniform on a discrete support. We show how to use a collection of such p-values to estimate the number of true null h...

The projection pursuit index defined by a sum of squares of the third and the fourth sample cumulants is known as the moment index proposed by Jones and Sibson [14]. Limiting distribution of the maximum of the moment index under the null hypothesis that the population is multivariate normal is shown to be the maximum of a Gaussian random field with a finite Karhunen-Loève expansion. An approxim...

OBJECTIVES/HYPOTHESIS The present tutorial is the seventh in a series of Tutorials in Clinical Research. The specific purpose of the tutorial (Part A) and its sequel (Part B) is to introduce and explain three commonly used statistical tools for assessing contrast in the comparison between two groups. STUDY DESIGN Tutorial. METHODS The authors met weekly for 10 months discussing clinical res...

This research is motivated by one of our survey studies to assess the potential influence of introducing zebra mussels to the Lake Mead National Recreation Area, Nevada. One research question in this study is to investigate the association between the boating activity type and the awareness of zebra mussels. A chi-squared test is often used for testing independence between two factors with nomi...