نتایج جستجو برای: p stat 1
تعداد نتایج: 3583417 فیلتر نتایج به سال:
Background and aim: Aberrant activation of diverse intracellular signaling pathways involved in differentiation, cell growth, apoptosis. These pathways include known oncogenic pathways such as Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway. The JAK/STAT signaling pathway plays an important role in many cellular functions. This pathway can be activated by variou...
The downstream of kinase (DOK)-1 is involved in the protein tyrosine kinase (PTK) pathway in mast cells, but the role of DOK-1 in the pathogenesis of asthma has not been defined. In this study, we have demonstrated a novel regulatory role of DOK-1 in airway inflammation and physiologic responses in a murine model of asthma using lentiviral vector containing DOK-1 cDNA or DOK-1-specific ShRNA. T...
STAT-3 and STAT-1 signaling have opposite effects in oncogenesis with STAT-3 acting as an oncogene and STAT-1 exerting anti-oncogenic activities through interferon-γ and interferon-α. The cytokine IL-6 promotes oncogenesis by stimulation of NFκB and STAT-3 signaling. Curcuminoids have bi-functional effects by blocking NFκB anti-apoptotic signaling but also blocking anti-oncogenic STAT-1 signali...
BACKGROUND Psoriatic arthritis (PsA) is a chronic inflammatory disease, characterised by synovitis and destruction of articular cartilage/bone. Janus-kinase and signal transducer and activator of transcription (JAK-STAT) signalling pathway is implicated in the pathogenesis of PsA. OBJECTIVES To examine the effect of tofacitinib (JAK inhibitor) on proinflammatory mechanisms in PsA. METHODS P...
CIS (cytokine-inducible SH2 protein), SOCS (suppressor of cytokine signaling), or SSI (signal transducers and activators of transcription [STAT]-induced STAT inhibitor) proteins are a family of cytokine-inducible negative regulators of cytokine signaling via Janus kinase (JAK)-STAT pathways. Given the evidence that the JAK-STAT pathway plays a critical role in the cardiovascular system, the pri...
We consider a p-dimensional, centered normal population such that all variables have positive variance σ2 and any correlation coefficient between different is given nonnegative constant ρ < 1. Suppose both the sample size n dimension p tend to infinity with p/n → c > 0. prove limiting spectral distribution of matrix Marcenko-Pastur index scale parameter 1 − ρ. By distributions, we rigorou...
Measurements of the gluon polarization ∆G G via the open charm channel and based on the helicity asymmetry of large transverse-momentum hadrons in the final state are presented. The data have been collected in the years 2002-2004 by the COMPASS experiment at CERN using a 160 GeV/c polarized muon beam scattered off a polarized 6LiD target. The new result for ∆G G from the charm channel is −0.57 ...
BACKGROUND Fulminant changes in cytokine receptor signalling might provoke severe pathological alterations after multiple trauma. The aim of this study was to evaluate the posttraumatic imbalance of the innate immune system with a special focus on the STAT/SOCS family. METHODS 20 polytraumatized patients were included. Blood samples were drawn 0 h-72 h after trauma; mRNA expression profiles o...
The lifetimes of charmed mesons have been measured using 11.1 fb −1 of data collected with the Belle detector at KEKB. Each candidate is fully reconstructed to identify the flavor of the charmed meson. The lifetimes are measured to be τ (D 0) = (414.5 ± 1.7(stat.)) fs, τ (D +) = (1029 ± 12(stat.)) fs and τ (D + s) = (488.4 +7.8 −7.7 (stat.)) fs, where the error is statistical only. The ratios o...
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